Functional significance of point mutations in stress chaperone mortalin and their relevance to parkinson disease

Renu Wadhwa, Jihoon Ryu, Hyo Min Ahn, Nishant Saxena, Anupama Chaudhary, Chae Ok Yun, Sunil C. Kaul

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Mortalin, an essential chaperone, is enriched in cancers; it possesses pro-proliferative and anti-apoptotic functions and has been found mutated in some Parkinson patients. Results: Mutant mortalins lack functions involved in carcinogenesis and cause increased oxidative stress; we demonstrate the factors and mechanism of their role in Parkinson disease. Conclusion: Mutations in mortalin contribute to Parkinson disease. Significance: This work contributes toward an understanding of mortalin-associated diseases for therapy.

Original languageEnglish
Pages (from-to)8447-8456
Number of pages10
JournalJournal of Biological Chemistry
Volume290
Issue number13
DOIs
StatePublished - 2015 Mar 27

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Point Mutation
Parkinson Disease
Oxidative stress
Carcinogenesis
Oxidative Stress
Mutation
mortalin
Neoplasms
Therapeutics

Cite this

Wadhwa, Renu ; Ryu, Jihoon ; Ahn, Hyo Min ; Saxena, Nishant ; Chaudhary, Anupama ; Yun, Chae Ok ; Kaul, Sunil C. / Functional significance of point mutations in stress chaperone mortalin and their relevance to parkinson disease. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 13. pp. 8447-8456.
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Functional significance of point mutations in stress chaperone mortalin and their relevance to parkinson disease. / Wadhwa, Renu; Ryu, Jihoon; Ahn, Hyo Min; Saxena, Nishant; Chaudhary, Anupama; Yun, Chae Ok; Kaul, Sunil C.

In: Journal of Biological Chemistry, Vol. 290, No. 13, 27.03.2015, p. 8447-8456.

Research output: Contribution to journalArticle

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AU - Yun, Chae Ok

AU - Kaul, Sunil C.

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