Fabrication and characterization of pseudo-ceramide-based liposomal membranes

Do Hoon Kim, Eun Jung An, Jongwon Kim, Sang Hoon Han, Jin Woong Kim, Seong Geun Oh, Kyung Do Suh, Eun Chul Cho

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We present a facile and straightforward method to fabricate liposomal membranes with a significantly stable lamellar structure consisting of pseudo-ceramide, fatty acid, and cholesterol. Characterizing their membrane properties, in which we have used differential scanning calorimetry, X-ray diffraction, and FT-IR spectra, enables us to demonstrate that pseudo-ceramide with appropriate amounts of stearic acid and cholesterol can assemble to form a stable lamellar α-phase. Moreover, we show that cholesterol is indeed important and plays a role in controlling the melting entropy of lipid membranes, which is attributed to a disordered molecular packing, thus creating more flexible liposomal membranes. This approach to use pseudo-ceramide offers a useful means to fabricate a variety of biocompatible liposomes with controllable membrane properties, which enlarges their applicability in the field of drug delivery, dermatology, and cosmetics.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalColloids and Surfaces B: Biointerfaces
Volume73
Issue number2
DOIs
StatePublished - 2009 Oct 15

Keywords

  • Lamellar
  • Liposomal
  • Membrane
  • Pseudo-ceramide
  • α-Phase

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