Extended-Gate Amorphous InGaZnO Thin Film Transistor for Biochemical Sensing

Jusin Lee, Min Jae Kim, Heewon Yang, Sunjin Kim, Seongoh Yeom, Gunwoo Ryu, Yoonsoo Shin, Onejae Sul, Jae Kyeong Jeong, Seung-Beck Lee

Research output: Contribution to journalArticlepeer-review

Abstract

We report on a stable and sensitive biochemical sensor based on amorphous indium-gallium-zinc-oxide (a-IGZO) thin-film transistors (TFTs) with a versatile extended-gate electrode used as the sensing membrane. The extended-gate allows the active transistor channel not to be exposed to the ionic analyte and the gate surface may be modified with chemicals or affinity reagents without affecting the operation of the active sensor. The extended-gate a-IGZO TFT was able to detect the pH levels of various solutions based on protonation and deprotonation at the surface of the indium-tin-oxide (ITO) extended-gate electrode achieving a pH dependent threshold voltage shift of 22.8 mV/pH. Highly sensitive and specific protein sensing was achieved for both electrical polarities according to pH values of solutions using the biotin-streptavidin interaction. The extended-gate TFT sensor demonstrated a detection limit for streptavidin down to 10 fM, using the biotin-streptavidin binding on the extended-gate surface. It was also possible to detect changes in the streptavidin concentration in real-time with specificity and repeatability. Since the extended-gate can be easily replaced without affecting the performance of the a-IGZO TFT, this sensor configuration may be utilized for future multifunctional biomolecular sensing and analysis.

Original languageEnglish
Article number9159616
Pages (from-to)178-184
Number of pages7
JournalIEEE Sensors Journal
Volume21
Issue number1
DOIs
StatePublished - 2021 Jan 1

Keywords

  • Biosensors
  • extended-gate field-effect transistors
  • pH sensors
  • real-time detection
  • thin film transistors

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