Exosome and polymersome for potential theranostic applications

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Nano-sized systems have been used extensively for the delivery of various therapeutics, such as pharmaceuticals, proteins, and nucleic acids. Exosomes are small extracellular vesicles secreted from parent cells by fusion of multivesicular late endosomes with the plasma membrane, which act as an intercellular communication mediator and contain bioactive molecules. Thus, exosomes may possess potential as a natural delivery system. Polymersomes are synthetic vesicles composed of external bilayers, typically generated from amphiphilic block copolymers, which resemble many aspects of exosomes and have been utilized widely in many drug delivery applications. In this review, general properties of exosomes and polymersomes and their recent applications in the drug delivery areas and potential in theranostic approaches are discussed. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)577-586
Number of pages10
JournalMacromolecular Research
Volume24
Issue number7
DOIs
StatePublished - 2016 Jul 1

Fingerprint

Drug delivery
Nucleic acids
Cell membranes
Drug products
Nucleic Acids
Block copolymers
Fusion reactions
Proteins
Molecules
Communication
Pharmaceutical Preparations

Keywords

  • drug delivery
  • exosome
  • extracellular vesicle
  • polymersome
  • theranosis

Cite this

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Exosome and polymersome for potential theranostic applications. / Rhim, Taiyoun; Lee, Kuen Yong.

In: Macromolecular Research, Vol. 24, No. 7, 01.07.2016, p. 577-586.

Research output: Contribution to journalReview article

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AB - Nano-sized systems have been used extensively for the delivery of various therapeutics, such as pharmaceuticals, proteins, and nucleic acids. Exosomes are small extracellular vesicles secreted from parent cells by fusion of multivesicular late endosomes with the plasma membrane, which act as an intercellular communication mediator and contain bioactive molecules. Thus, exosomes may possess potential as a natural delivery system. Polymersomes are synthetic vesicles composed of external bilayers, typically generated from amphiphilic block copolymers, which resemble many aspects of exosomes and have been utilized widely in many drug delivery applications. In this review, general properties of exosomes and polymersomes and their recent applications in the drug delivery areas and potential in theranostic approaches are discussed. [Figure not available: see fulltext.]

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