Evolving lessons on nanomaterial-coated viral vectors for local and systemic gene therapy

Dayananda Kasala, A. Rum Yoon, Jinwoo Hong, Sung Wan Kim, Chae Ok Yun

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Viral vectors are promising gene carriers for cancer therapy. However, virus-mediated gene therapies have demonstrated insufficient therapeutic efficacy in clinical trials due to rapid dissemination to nontarget tissues and to the immunogenicity of viral vectors, resulting in poor retention at the disease locus and induction of adverse inflammatory responses in patients. Further, the limited tropism of viral vectors prevents efficient gene delivery to target tissues. In this regard, modification of the viral surface with nanomaterials is a promising strategy to augment vector accumulation at the target tissue, circumvent the host immune response, and avoid nonspecific interactions with the reticuloendothelial system or serum complement. In the present review, we discuss various chemical modification strategies to enhance the therapeutic efficacy of viral vectors delivered either locally or systemically. We conclude by highlighting the salient features of various nanomaterial-coated viral vectors and their prospects and directions for future research.

Original languageEnglish
Pages (from-to)1689-1713
Number of pages25
JournalNanomedicine
Volume11
Issue number13
DOIs
StatePublished - 2016 Jul

Keywords

  • adeno-associated virus
  • adenovirus
  • bioreducible polymers
  • cationic polymers
  • gene therapy
  • hydrogels
  • lentivirus
  • local delivery
  • systemic administration
  • viral vectors

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