Electroacupuncture may relax the sphincter of Oddi in humans

Sung Koo Lee, Myung Hwan Kim, Hong Ja Kim, Dong Wan Seo, Kyo-Sang Yoo, Yun Ho Joo, Young Il Min, Ji Hoon Kim, Byung Il Min

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: This study was designed to evaluate the effects of electroacupuncture on sphincter of Oddi (SO) motility in humans and to associate the manometric findings with cholecystokinin (CCK) plasma levels. Methods: Eleven patients (M:F = 5:6) with various kinds of biliary disorders were enrolled. SO motility was monitored with conventional low-compliance, continuous perfusion technique at ERCP (n = 9) or via percutaneous transhepatic cholangioscopy (n = 2). After baseline monitoring for phasic wave contractions of SO, electroacupuncture was applied at a specific acupoint GB 34. A nonspecific acupoint 5 cm away from GB 34 was selected as a control. Manometric parameters of the SO were also measured in 6 subjects during stimulation of the control acupoint. CCK plasma levels were measured during electroacupuncture stimulation. Results: All manometric parameters including basal pressure, amplitude, frequency, and duration of phasic wave contractions of the SO were significantly decreased (p < 0.05) during electroacupuncture stimulation. The inhibition of SO contractility was accompanied by increased CCK plasma levels. After discontinuation of electroacupuncture stimulation, restoration of amplitude and duration to basal conditions was noted. A tendency toward return of SO basal pressure and contractile frequency to baseline was also observed. Stimulation of the control acupoint did not affect SO contractility. Conclusion: Electroacupuncture stimulation of acupoint GB 34 resulted in reversible inhibition of SO contraction in humans. The response of SO to electroacupuncture stimulation may be mediated by some neurohormonal mechanisms including CCK release.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalGastrointestinal Endoscopy
Volume53
Issue number2
DOIs
StatePublished - 2001 Jan 1

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Sphincter of Oddi
Electroacupuncture
Acupuncture Points
Cholecystokinin
Pressure
Endoscopic Retrograde Cholangiopancreatography
Compliance
Perfusion

Cite this

Lee, S. K., Kim, M. H., Kim, H. J., Seo, D. W., Yoo, K-S., Joo, Y. H., ... Min, B. I. (2001). Electroacupuncture may relax the sphincter of Oddi in humans. Gastrointestinal Endoscopy, 53(2), 211-216. https://doi.org/10.1067/mge.2001.112180
Lee, Sung Koo ; Kim, Myung Hwan ; Kim, Hong Ja ; Seo, Dong Wan ; Yoo, Kyo-Sang ; Joo, Yun Ho ; Min, Young Il ; Kim, Ji Hoon ; Min, Byung Il. / Electroacupuncture may relax the sphincter of Oddi in humans. In: Gastrointestinal Endoscopy. 2001 ; Vol. 53, No. 2. pp. 211-216.
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abstract = "Background: This study was designed to evaluate the effects of electroacupuncture on sphincter of Oddi (SO) motility in humans and to associate the manometric findings with cholecystokinin (CCK) plasma levels. Methods: Eleven patients (M:F = 5:6) with various kinds of biliary disorders were enrolled. SO motility was monitored with conventional low-compliance, continuous perfusion technique at ERCP (n = 9) or via percutaneous transhepatic cholangioscopy (n = 2). After baseline monitoring for phasic wave contractions of SO, electroacupuncture was applied at a specific acupoint GB 34. A nonspecific acupoint 5 cm away from GB 34 was selected as a control. Manometric parameters of the SO were also measured in 6 subjects during stimulation of the control acupoint. CCK plasma levels were measured during electroacupuncture stimulation. Results: All manometric parameters including basal pressure, amplitude, frequency, and duration of phasic wave contractions of the SO were significantly decreased (p < 0.05) during electroacupuncture stimulation. The inhibition of SO contractility was accompanied by increased CCK plasma levels. After discontinuation of electroacupuncture stimulation, restoration of amplitude and duration to basal conditions was noted. A tendency toward return of SO basal pressure and contractile frequency to baseline was also observed. Stimulation of the control acupoint did not affect SO contractility. Conclusion: Electroacupuncture stimulation of acupoint GB 34 resulted in reversible inhibition of SO contraction in humans. The response of SO to electroacupuncture stimulation may be mediated by some neurohormonal mechanisms including CCK release.",
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Lee, SK, Kim, MH, Kim, HJ, Seo, DW, Yoo, K-S, Joo, YH, Min, YI, Kim, JH & Min, BI 2001, 'Electroacupuncture may relax the sphincter of Oddi in humans', Gastrointestinal Endoscopy, vol. 53, no. 2, pp. 211-216. https://doi.org/10.1067/mge.2001.112180

Electroacupuncture may relax the sphincter of Oddi in humans. / Lee, Sung Koo; Kim, Myung Hwan; Kim, Hong Ja; Seo, Dong Wan; Yoo, Kyo-Sang; Joo, Yun Ho; Min, Young Il; Kim, Ji Hoon; Min, Byung Il.

In: Gastrointestinal Endoscopy, Vol. 53, No. 2, 01.01.2001, p. 211-216.

Research output: Contribution to journalArticle

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AU - Kim, Myung Hwan

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AU - Min, Young Il

AU - Kim, Ji Hoon

AU - Min, Byung Il

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N2 - Background: This study was designed to evaluate the effects of electroacupuncture on sphincter of Oddi (SO) motility in humans and to associate the manometric findings with cholecystokinin (CCK) plasma levels. Methods: Eleven patients (M:F = 5:6) with various kinds of biliary disorders were enrolled. SO motility was monitored with conventional low-compliance, continuous perfusion technique at ERCP (n = 9) or via percutaneous transhepatic cholangioscopy (n = 2). After baseline monitoring for phasic wave contractions of SO, electroacupuncture was applied at a specific acupoint GB 34. A nonspecific acupoint 5 cm away from GB 34 was selected as a control. Manometric parameters of the SO were also measured in 6 subjects during stimulation of the control acupoint. CCK plasma levels were measured during electroacupuncture stimulation. Results: All manometric parameters including basal pressure, amplitude, frequency, and duration of phasic wave contractions of the SO were significantly decreased (p < 0.05) during electroacupuncture stimulation. The inhibition of SO contractility was accompanied by increased CCK plasma levels. After discontinuation of electroacupuncture stimulation, restoration of amplitude and duration to basal conditions was noted. A tendency toward return of SO basal pressure and contractile frequency to baseline was also observed. Stimulation of the control acupoint did not affect SO contractility. Conclusion: Electroacupuncture stimulation of acupoint GB 34 resulted in reversible inhibition of SO contraction in humans. The response of SO to electroacupuncture stimulation may be mediated by some neurohormonal mechanisms including CCK release.

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