Effects of poloxamer-based thermo-sensitive sol–gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia: a multicentre, single-blinded, randomised controlled trial

Jae Hoon Chung, Kyu Shik Kim, Jae Duck Choi, Tae Hyo Kim, Ki Soo Lee, Cheol Young Oh, Joon Hwa Noh, Jun Seok Kim, Won Tae Kim, Seung Hwan Lee, Jae Heon Kim, Tae Nam Kim, Wan Huh, Seung Wook Lee

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the effectiveness of poloxamer-based thermo-sensitive sol–gel instillation, after transurethral resection of the prostate (TURP), for preventing urethral stricture. Patients and Methods: In all, 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: groups A and B. Patients in Group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol–gel instillation and patients in the Group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 (V1), 12 (V2), and 24 weeks (V3) after TURP. The effectiveness of poloxamer-based thermo-sensitive sol–gel instillation was evaluated based on the International Prostate Symptom Score (IPSS), IPSS-Quality of Life (QoL), Overactive bladder questionnaire (OAB-q), maximum urinary flow rate (Qmax), post-void residual urine volume (PVR), and cystoscopy. Results: Amongst the initial 198 participants, 80 patients in Group A and 83 in Group B completed the study. There were no significant differences in IPSS-QoL and OAB-q between the groups. However, Qmax was significantly different between groups A and B, at a mean (SD) of 18.92 (9.98) vs 15.58 (9.24) mL/s (P = 0.028) at 24 weeks after TURP. On cystoscopic examination, urethral stricture after TURP was found in two of the 80 patients in Group A and 10 of 83 in Group B (P = 0.023). Conclusions: Poloxamer-based thermo-sensitive sol–gel instillation after TURP lowered the incidence of urethral stricture.

Original languageEnglish
Pages (from-to)160-167
Number of pages8
JournalBJU International
Volume125
Issue number1
DOIs
StatePublished - 2020 Jan 1

Fingerprint

Poloxamer
Urethral Stricture
Transurethral Resection of Prostate
Prostatic Hyperplasia
Randomized Controlled Trials
Prostate
Overactive Urinary Bladder
Nijmegen Breakage Syndrome
Quality of Life
Lubricants
Cystoscopy
Residual Volume
Urine

Keywords

  • #UroBPH
  • chitosan
  • gelatine
  • poloxamer
  • prostatic hyperplasia
  • transurethral resection of prostate
  • urethral stricture

Cite this

Chung, Jae Hoon ; Kim, Kyu Shik ; Choi, Jae Duck ; Kim, Tae Hyo ; Lee, Ki Soo ; Oh, Cheol Young ; Noh, Joon Hwa ; Kim, Jun Seok ; Kim, Won Tae ; Lee, Seung Hwan ; Kim, Jae Heon ; Kim, Tae Nam ; Huh, Wan ; Lee, Seung Wook. / Effects of poloxamer-based thermo-sensitive sol–gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia : a multicentre, single-blinded, randomised controlled trial. In: BJU International. 2020 ; Vol. 125, No. 1. pp. 160-167.
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title = "Effects of poloxamer-based thermo-sensitive sol–gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia: a multicentre, single-blinded, randomised controlled trial",
abstract = "Objective: To evaluate the effectiveness of poloxamer-based thermo-sensitive sol–gel instillation, after transurethral resection of the prostate (TURP), for preventing urethral stricture. Patients and Methods: In all, 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: groups A and B. Patients in Group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol–gel instillation and patients in the Group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 (V1), 12 (V2), and 24 weeks (V3) after TURP. The effectiveness of poloxamer-based thermo-sensitive sol–gel instillation was evaluated based on the International Prostate Symptom Score (IPSS), IPSS-Quality of Life (QoL), Overactive bladder questionnaire (OAB-q), maximum urinary flow rate (Qmax), post-void residual urine volume (PVR), and cystoscopy. Results: Amongst the initial 198 participants, 80 patients in Group A and 83 in Group B completed the study. There were no significant differences in IPSS-QoL and OAB-q between the groups. However, Qmax was significantly different between groups A and B, at a mean (SD) of 18.92 (9.98) vs 15.58 (9.24) mL/s (P = 0.028) at 24 weeks after TURP. On cystoscopic examination, urethral stricture after TURP was found in two of the 80 patients in Group A and 10 of 83 in Group B (P = 0.023). Conclusions: Poloxamer-based thermo-sensitive sol–gel instillation after TURP lowered the incidence of urethral stricture.",
keywords = "#UroBPH, chitosan, gelatine, poloxamer, prostatic hyperplasia, transurethral resection of prostate, urethral stricture",
author = "Chung, {Jae Hoon} and Kim, {Kyu Shik} and Choi, {Jae Duck} and Kim, {Tae Hyo} and Lee, {Ki Soo} and Oh, {Cheol Young} and Noh, {Joon Hwa} and Kim, {Jun Seok} and Kim, {Won Tae} and Lee, {Seung Hwan} and Kim, {Jae Heon} and Kim, {Tae Nam} and Wan Huh and Lee, {Seung Wook}",
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Effects of poloxamer-based thermo-sensitive sol–gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia : a multicentre, single-blinded, randomised controlled trial. / Chung, Jae Hoon; Kim, Kyu Shik; Choi, Jae Duck; Kim, Tae Hyo; Lee, Ki Soo; Oh, Cheol Young; Noh, Joon Hwa; Kim, Jun Seok; Kim, Won Tae; Lee, Seung Hwan; Kim, Jae Heon; Kim, Tae Nam; Huh, Wan; Lee, Seung Wook.

In: BJU International, Vol. 125, No. 1, 01.01.2020, p. 160-167.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of poloxamer-based thermo-sensitive sol–gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia

T2 - a multicentre, single-blinded, randomised controlled trial

AU - Chung, Jae Hoon

AU - Kim, Kyu Shik

AU - Choi, Jae Duck

AU - Kim, Tae Hyo

AU - Lee, Ki Soo

AU - Oh, Cheol Young

AU - Noh, Joon Hwa

AU - Kim, Jun Seok

AU - Kim, Won Tae

AU - Lee, Seung Hwan

AU - Kim, Jae Heon

AU - Kim, Tae Nam

AU - Huh, Wan

AU - Lee, Seung Wook

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Objective: To evaluate the effectiveness of poloxamer-based thermo-sensitive sol–gel instillation, after transurethral resection of the prostate (TURP), for preventing urethral stricture. Patients and Methods: In all, 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: groups A and B. Patients in Group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol–gel instillation and patients in the Group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 (V1), 12 (V2), and 24 weeks (V3) after TURP. The effectiveness of poloxamer-based thermo-sensitive sol–gel instillation was evaluated based on the International Prostate Symptom Score (IPSS), IPSS-Quality of Life (QoL), Overactive bladder questionnaire (OAB-q), maximum urinary flow rate (Qmax), post-void residual urine volume (PVR), and cystoscopy. Results: Amongst the initial 198 participants, 80 patients in Group A and 83 in Group B completed the study. There were no significant differences in IPSS-QoL and OAB-q between the groups. However, Qmax was significantly different between groups A and B, at a mean (SD) of 18.92 (9.98) vs 15.58 (9.24) mL/s (P = 0.028) at 24 weeks after TURP. On cystoscopic examination, urethral stricture after TURP was found in two of the 80 patients in Group A and 10 of 83 in Group B (P = 0.023). Conclusions: Poloxamer-based thermo-sensitive sol–gel instillation after TURP lowered the incidence of urethral stricture.

AB - Objective: To evaluate the effectiveness of poloxamer-based thermo-sensitive sol–gel instillation, after transurethral resection of the prostate (TURP), for preventing urethral stricture. Patients and Methods: In all, 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: groups A and B. Patients in Group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol–gel instillation and patients in the Group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 (V1), 12 (V2), and 24 weeks (V3) after TURP. The effectiveness of poloxamer-based thermo-sensitive sol–gel instillation was evaluated based on the International Prostate Symptom Score (IPSS), IPSS-Quality of Life (QoL), Overactive bladder questionnaire (OAB-q), maximum urinary flow rate (Qmax), post-void residual urine volume (PVR), and cystoscopy. Results: Amongst the initial 198 participants, 80 patients in Group A and 83 in Group B completed the study. There were no significant differences in IPSS-QoL and OAB-q between the groups. However, Qmax was significantly different between groups A and B, at a mean (SD) of 18.92 (9.98) vs 15.58 (9.24) mL/s (P = 0.028) at 24 weeks after TURP. On cystoscopic examination, urethral stricture after TURP was found in two of the 80 patients in Group A and 10 of 83 in Group B (P = 0.023). Conclusions: Poloxamer-based thermo-sensitive sol–gel instillation after TURP lowered the incidence of urethral stricture.

KW - #UroBPH

KW - chitosan

KW - gelatine

KW - poloxamer

KW - prostatic hyperplasia

KW - transurethral resection of prostate

KW - urethral stricture

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U2 - 10.1111/bju.14902

DO - 10.1111/bju.14902

M3 - Article

C2 - 31444917

AN - SCOPUS:85073945497

VL - 125

SP - 160

EP - 167

JO - BJU International

JF - BJU International

SN - 1464-4096

IS - 1

ER -