Development of smart delivery system for ascorbic acid using pH-responsive P(MAA-co-EGMA) hydrogel microparticles

Eunmi Lee, Kyusik Kim, Moonjae Choi, Youngmoo Lee, Jin Won Park, Bumsang Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

pH-Responsive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility as intelligent delivery carriers was evaluated. P(MAA-co-EGMA) hydrogel microparticles were synthesized via dispersion photopolymerization. There was a drastic change in the swelling ratio of P(MAA-co-EGMA) microparticles at a pH of ~ 5 and, as the amount of MAA in the hydrogel increased, the swelling ratio increased at a pH above 5. The loading efficiency of the ascorbic acid into the hydrogel was affected more by the degree of swelling of the hydrogel than the electrostatic interaction between the hydrogel and the loaded ascorbic acid. The P(MAA-co-EGMA) hydrogel microparticles showed a pH-sensitive release behavior. Thus, at pH 4 almost none of the ascorbic acid permeated through the skin while at pH 6 relatively high skin permeability was obtained. The ascorbic acid loaded in the hydrogel particles was hardly degraded and its stability was maintained at high temperature.

Original languageEnglish
Pages (from-to)573-580
Number of pages8
JournalDrug Delivery
Volume17
Issue number8
DOIs
StatePublished - 2010 Nov 1

Fingerprint

Hydrogel
Ascorbic Acid
Skin
Static Electricity
Permeability
Temperature

Keywords

  • Ascorbic acid stability
  • Hydrogel microparticles
  • Intelligent delivery system
  • PH-responsive
  • Skin permeability.

Cite this

Lee, Eunmi ; Kim, Kyusik ; Choi, Moonjae ; Lee, Youngmoo ; Park, Jin Won ; Kim, Bumsang. / Development of smart delivery system for ascorbic acid using pH-responsive P(MAA-co-EGMA) hydrogel microparticles. In: Drug Delivery. 2010 ; Vol. 17, No. 8. pp. 573-580.
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Development of smart delivery system for ascorbic acid using pH-responsive P(MAA-co-EGMA) hydrogel microparticles. / Lee, Eunmi; Kim, Kyusik; Choi, Moonjae; Lee, Youngmoo; Park, Jin Won; Kim, Bumsang.

In: Drug Delivery, Vol. 17, No. 8, 01.11.2010, p. 573-580.

Research output: Contribution to journalArticle

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