Development of electroactive and elastic nanofibers that contain polyaniline and poly(L-lactide-co-ε-caprolactone) for the control of cell adhesion

Sung In Jeong, In Dong Jun, Moon Jae Choi, Young Chang Nho, Young Moo Lee, Heungsoo Shin

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

In this work, electrically conductive polyaniline (PAni) doped with camphorsulfonic acid (CPSA) is blended with poly(L-lactide-co-ε-caprolactone) (PLCL), and then electrospun to prepare uniform nanofibers. The CPSA-PAni/PLCL nanofibers show a smooth fiber structure without coarse lumps or beads and consistent fiber diameters (which range from 100 to 700 nm) even with an increase in the amount of CPSA-PAni (from 0 to 30 wt.-%). However, the elongation at break decreases from 391.54 ± 9.20% to 207.85 ± 6.74% when 30% of CPSA-PAni is incorporated. Analysis of the surface of the nanofibers demonstrates the presence of homogeneously blended CPSA-PAni. Most importantly, a four-point probe analysis reveals that electrical properties are maintained in the nanofibers where the conductivity is significantly increased from 0.0015 to 0.0138 S·cm-1 when the nanofibers are prepared with 30% CPSA-PAni. The cell adhesion tests using human dermal fibroblasts, NIH-3T3 fibroblasts, and C2C12 myoblasts demonstrate significantly higher adhesion on the CPSA-PAni/PLCL nanofibers than pure PLCL nanofibers. In addition, the growth of NIH-3T3 fibroblasts is enhanced under the stimulation of various direct current flows. The CPSA-PAni/PLCL nanofibers with electrically conductive properties may potentially be used as a platform substrate to study the effect of electrical signals on cell activities and to direct desirable cell function for tissue engineering applications. A figure is presented.

Original languageEnglish
Pages (from-to)627-637
Number of pages11
JournalMacromolecular Bioscience
Volume8
Issue number7
DOIs
StatePublished - 2008 Jul 7

Keywords

  • Conducting polymers
  • Electrospinning
  • Nanofibers
  • Poly(L-lactide-co-ε-caprolactone)
  • Polyaniline

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