Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery

Jong Hoon Ha, Dae Yong Lee, Soo Hwan Lee, Chae Ok Yun, Yeu Chun Kim

Research output: Contribution to journalArticle

Abstract

Mitochondria are the primary organelle of regulating apoptosis, and intracellular calcium ions are a key component of pro-apoptosis induction. Herein, we report an artificial apoptosis-inducing polypeptide that destabilizes the mitochondrial membrane and transports calcium ions into the cytosol, thereby synergistically creating severe oxidative conditions. The oxidative stress highly activates an apoptotic signaling cascade, and also inhibits cell migration and invasion in vitro and in vivo. The suggested strategy for simultaneous mitochondrial disruption and perturbed calcium homeostasis demonstrates the applicability of polypeptide-based therapeutics as potent apoptosis-inducers in cancer therapy.

Original languageEnglish
Pages (from-to)51-59
Number of pages9
JournalBiomaterials
Volume197
DOIs
StatePublished - 2019 Mar 1

Fingerprint

Polypeptides
Mitochondrial Membranes
Cell death
Apoptosis
Membranes
Calcium
Peptides
Ions
Mitochondria
Oxidative stress
Ion Transport
Organelles
Cytosol
Cell Movement
Oxidative Stress
Homeostasis
Therapeutics
Neoplasms

Keywords

  • Anti-cancer polypeptide
  • Calcium ion delivery
  • Mitochondrial membrane destabilization
  • Pro-apoptotic activity

Cite this

Ha, Jong Hoon ; Lee, Dae Yong ; Lee, Soo Hwan ; Yun, Chae Ok ; Kim, Yeu Chun. / Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery. In: Biomaterials. 2019 ; Vol. 197. pp. 51-59.
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Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery. / Ha, Jong Hoon; Lee, Dae Yong; Lee, Soo Hwan; Yun, Chae Ok; Kim, Yeu Chun.

In: Biomaterials, Vol. 197, 01.03.2019, p. 51-59.

Research output: Contribution to journalArticle

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AU - Kim, Yeu Chun

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KW - Calcium ion delivery

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