Development of acrylic acid grafted polycaprolactone (PCL)/biphasic calcium phosphate (BCP) nanofibers for bone tissue engineering using gamma-irradiation

Jin Oh Jeong, Sung In Jeong, Young Min Shin, Jong Seok Park, Hui Jeong Gwon, Sung Jun An, Jung Bo Huh, Heungsoo Shin, Youn Mook Lim

Research output: Contribution to journalArticle

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Abstract

Polycaprolactone (PCL) and biphasic calcium phosphate (BCP) have been considered as useful materials for orthopedic devices and osseous implants because of their biocompatibility and bone-forming activity. However, PCL-based scaffolds have hydrophobic surfaces reducing initial cell adhesion or proliferation. To overcome the limitation, we fabricated surface-modified PCL/BCP nanofibers using gamma-irradiation for bone tissue engineering. PCL/BCP nanofibers were prepared by electrospinning and then we supplemented hydrophilicity by introducing acrylic acid (AAc) through gamma-irradiation. We confirmed the surface of nanofibers by SEM, and then the initial viability of MG63 was significantly increased on the AAc grafted nanofibers, and alkaline phosphatase activity(1.239±0.226 nmole/ug/min) improved on the modified nanofibers than that on the non-modified nanofibers(0.590±0.286 nmole/ug/min). Therefore, AAc-grafted nanofibers may be a good tool for bone tissue engineering applications.

Original languageEnglish
Pages (from-to)418-425
Number of pages8
JournalPolymer (Korea)
Volume39
Issue number3
DOIs
Publication statusPublished - 2015 May 1

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Keywords

  • Acrylic acid
  • Biphasic calcium phosphate
  • Bone tissue engineering
  • Electrospinning
  • Gamma-irradiation
  • Polycaprolactone

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