Delayed biliary-to-bowel transit in cholescintigraphy after cholecystokinin treatment

Chun Ki Kim, C. J. Palestro, R. W. Solomon, D. S. Molinari, S. O. Lee, S. J. Goldsmith

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Abstract

The authors assessed the influence of cholecystokinin (CCK), administered before cholescintigraphy, on the biliary-to-bowel transit time (BBTT) of technetium-99m disofenin. Fourteen healthy volunteers underwent two separate cholescintigraphic studies with and without CCK treatment. BBTT was less then 1 hour in all 14 studies of subjects not treated with CCK. In 14 subjects treated with CCK, there was no tracer activity in the bowel up to 2 hours in seven (50%) (P = .006). Eighty-three cholescintigrams obtained in patients with suspected acute cholecystitis were also retrospectively analyzed. In 53 of 83 patients in whom the gallbladder was visualized within 1 hour, significantly delayed BBTT was found in 14 of 29 (48%) who received CCK, compared with the BBTT in one of 24 patients (4%) who did not receive CCK (P < .001). In the 30 patients in whom the gallbladder was never visualized (n = 28) or was visualized after 1 hour (n = 2), BBTT was less than 30 minutes, regardless of whether patients were treated with CCK. Results show that CCK treatment causes significantly delayed BBTT in many cases, and this finding should not be interpreted as abnormal.

Original languageEnglish
Pages (from-to)553-556
Number of pages4
JournalRadiology
Volume176
Issue number2
DOIs
StatePublished - 1990 Jan 1

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Cholecystokinin
Therapeutics
Gallbladder
Technetium Tc 99m Disofenin
Acute Cholecystitis
Healthy Volunteers

Cite this

Kim, C. K., Palestro, C. J., Solomon, R. W., Molinari, D. S., Lee, S. O., & Goldsmith, S. J. (1990). Delayed biliary-to-bowel transit in cholescintigraphy after cholecystokinin treatment. Radiology, 176(2), 553-556. https://doi.org/10.1148/radiology.176.2.2367674
Kim, Chun Ki ; Palestro, C. J. ; Solomon, R. W. ; Molinari, D. S. ; Lee, S. O. ; Goldsmith, S. J. / Delayed biliary-to-bowel transit in cholescintigraphy after cholecystokinin treatment. In: Radiology. 1990 ; Vol. 176, No. 2. pp. 553-556.
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abstract = "The authors assessed the influence of cholecystokinin (CCK), administered before cholescintigraphy, on the biliary-to-bowel transit time (BBTT) of technetium-99m disofenin. Fourteen healthy volunteers underwent two separate cholescintigraphic studies with and without CCK treatment. BBTT was less then 1 hour in all 14 studies of subjects not treated with CCK. In 14 subjects treated with CCK, there was no tracer activity in the bowel up to 2 hours in seven (50{\%}) (P = .006). Eighty-three cholescintigrams obtained in patients with suspected acute cholecystitis were also retrospectively analyzed. In 53 of 83 patients in whom the gallbladder was visualized within 1 hour, significantly delayed BBTT was found in 14 of 29 (48{\%}) who received CCK, compared with the BBTT in one of 24 patients (4{\%}) who did not receive CCK (P < .001). In the 30 patients in whom the gallbladder was never visualized (n = 28) or was visualized after 1 hour (n = 2), BBTT was less than 30 minutes, regardless of whether patients were treated with CCK. Results show that CCK treatment causes significantly delayed BBTT in many cases, and this finding should not be interpreted as abnormal.",
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Kim, CK, Palestro, CJ, Solomon, RW, Molinari, DS, Lee, SO & Goldsmith, SJ 1990, 'Delayed biliary-to-bowel transit in cholescintigraphy after cholecystokinin treatment', Radiology, vol. 176, no. 2, pp. 553-556. https://doi.org/10.1148/radiology.176.2.2367674

Delayed biliary-to-bowel transit in cholescintigraphy after cholecystokinin treatment. / Kim, Chun Ki; Palestro, C. J.; Solomon, R. W.; Molinari, D. S.; Lee, S. O.; Goldsmith, S. J.

In: Radiology, Vol. 176, No. 2, 01.01.1990, p. 553-556.

Research output: Contribution to journalArticle

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