Cytomegalovirus infection in patients with new onset ulcerative colitis: A prospective study

You Sun Kim, Young Ho Kim, Joo Sung Kim, Jae Hee Cheon, Byong Duk Ye, Sung Ae Jung, Young Sook Park, Chang Hwan Choi, Byung Ik Jang, Dong Soo Han, Suk Kyun Yang, Won Ho Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background/Aims: Immunosuppressive therapy in ulcerative colitis (UC) may induce cytomegalovirus (CMV) infection or reactivation in the colonic mucosa and in turn exacerbate UC. However, it is unclear whether colonic inflammation itself affects CMV infection in UC. This prospective study evaluated the prevalence and clinical outcome of CMV infection in patients with new onset UC who have not been exposed to UC medication. Methodology: A prospective, multi-center study was conducted in 65 patients with new onset UC. The presence of CMV was evaluated by a serology test and a histopathological examination including immunohistochemical staining. The assessment of clinical outcome was performed based on CMV positivity. Results: Evidence of CMV infection was found in three (4.5%) patients with UC. Two patients with moderate disease activity improved with 5-aminosalicylate or steroid treatment. One patient with severe active colitis, however, required antiviral therapy. Conclusions: CMV infection is rare in new onset UC, which suggests that use of immunosuppressive medications is an important risk factor for CMV infection in UC. However, CMV evaluation is necessary for severe active UC, even with new onset of the disease.

Original languageEnglish
Pages (from-to)1098-1101
Number of pages4
JournalHepato-gastroenterology
Volume59
Issue number116
DOIs
StatePublished - 2012 Jun 1

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Cytomegalovirus Infections
Ulcerative Colitis
Prospective Studies
Cytomegalovirus
Immunosuppressive Agents
Mesalamine
Serology
Colitis
Antiviral Agents
Mucous Membrane
Therapeutics
Steroids
Outcome Assessment (Health Care)
Staining and Labeling
Inflammation

Keywords

  • Cytomegalovirus
  • Inflammation
  • Ulcerative colitis

Cite this

Kim, Y. S., Kim, Y. H., Kim, J. S., Cheon, J. H., Ye, B. D., Jung, S. A., ... Kim, W. H. (2012). Cytomegalovirus infection in patients with new onset ulcerative colitis: A prospective study. Hepato-gastroenterology, 59(116), 1098-1101. https://doi.org/10.5754/hge10217
Kim, You Sun ; Kim, Young Ho ; Kim, Joo Sung ; Cheon, Jae Hee ; Ye, Byong Duk ; Jung, Sung Ae ; Park, Young Sook ; Choi, Chang Hwan ; Jang, Byung Ik ; Han, Dong Soo ; Yang, Suk Kyun ; Kim, Won Ho. / Cytomegalovirus infection in patients with new onset ulcerative colitis : A prospective study. In: Hepato-gastroenterology. 2012 ; Vol. 59, No. 116. pp. 1098-1101.
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abstract = "Background/Aims: Immunosuppressive therapy in ulcerative colitis (UC) may induce cytomegalovirus (CMV) infection or reactivation in the colonic mucosa and in turn exacerbate UC. However, it is unclear whether colonic inflammation itself affects CMV infection in UC. This prospective study evaluated the prevalence and clinical outcome of CMV infection in patients with new onset UC who have not been exposed to UC medication. Methodology: A prospective, multi-center study was conducted in 65 patients with new onset UC. The presence of CMV was evaluated by a serology test and a histopathological examination including immunohistochemical staining. The assessment of clinical outcome was performed based on CMV positivity. Results: Evidence of CMV infection was found in three (4.5{\%}) patients with UC. Two patients with moderate disease activity improved with 5-aminosalicylate or steroid treatment. One patient with severe active colitis, however, required antiviral therapy. Conclusions: CMV infection is rare in new onset UC, which suggests that use of immunosuppressive medications is an important risk factor for CMV infection in UC. However, CMV evaluation is necessary for severe active UC, even with new onset of the disease.",
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Kim, YS, Kim, YH, Kim, JS, Cheon, JH, Ye, BD, Jung, SA, Park, YS, Choi, CH, Jang, BI, Han, DS, Yang, SK & Kim, WH 2012, 'Cytomegalovirus infection in patients with new onset ulcerative colitis: A prospective study', Hepato-gastroenterology, vol. 59, no. 116, pp. 1098-1101. https://doi.org/10.5754/hge10217

Cytomegalovirus infection in patients with new onset ulcerative colitis : A prospective study. / Kim, You Sun; Kim, Young Ho; Kim, Joo Sung; Cheon, Jae Hee; Ye, Byong Duk; Jung, Sung Ae; Park, Young Sook; Choi, Chang Hwan; Jang, Byung Ik; Han, Dong Soo; Yang, Suk Kyun; Kim, Won Ho.

In: Hepato-gastroenterology, Vol. 59, No. 116, 01.06.2012, p. 1098-1101.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cytomegalovirus infection in patients with new onset ulcerative colitis

T2 - A prospective study

AU - Kim, You Sun

AU - Kim, Young Ho

AU - Kim, Joo Sung

AU - Cheon, Jae Hee

AU - Ye, Byong Duk

AU - Jung, Sung Ae

AU - Park, Young Sook

AU - Choi, Chang Hwan

AU - Jang, Byung Ik

AU - Han, Dong Soo

AU - Yang, Suk Kyun

AU - Kim, Won Ho

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Background/Aims: Immunosuppressive therapy in ulcerative colitis (UC) may induce cytomegalovirus (CMV) infection or reactivation in the colonic mucosa and in turn exacerbate UC. However, it is unclear whether colonic inflammation itself affects CMV infection in UC. This prospective study evaluated the prevalence and clinical outcome of CMV infection in patients with new onset UC who have not been exposed to UC medication. Methodology: A prospective, multi-center study was conducted in 65 patients with new onset UC. The presence of CMV was evaluated by a serology test and a histopathological examination including immunohistochemical staining. The assessment of clinical outcome was performed based on CMV positivity. Results: Evidence of CMV infection was found in three (4.5%) patients with UC. Two patients with moderate disease activity improved with 5-aminosalicylate or steroid treatment. One patient with severe active colitis, however, required antiviral therapy. Conclusions: CMV infection is rare in new onset UC, which suggests that use of immunosuppressive medications is an important risk factor for CMV infection in UC. However, CMV evaluation is necessary for severe active UC, even with new onset of the disease.

AB - Background/Aims: Immunosuppressive therapy in ulcerative colitis (UC) may induce cytomegalovirus (CMV) infection or reactivation in the colonic mucosa and in turn exacerbate UC. However, it is unclear whether colonic inflammation itself affects CMV infection in UC. This prospective study evaluated the prevalence and clinical outcome of CMV infection in patients with new onset UC who have not been exposed to UC medication. Methodology: A prospective, multi-center study was conducted in 65 patients with new onset UC. The presence of CMV was evaluated by a serology test and a histopathological examination including immunohistochemical staining. The assessment of clinical outcome was performed based on CMV positivity. Results: Evidence of CMV infection was found in three (4.5%) patients with UC. Two patients with moderate disease activity improved with 5-aminosalicylate or steroid treatment. One patient with severe active colitis, however, required antiviral therapy. Conclusions: CMV infection is rare in new onset UC, which suggests that use of immunosuppressive medications is an important risk factor for CMV infection in UC. However, CMV evaluation is necessary for severe active UC, even with new onset of the disease.

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