Cross-reactivities of mammalian MAPKs antibodies in rotifer and copepod: Application in mechanistic studies in aquatic ecotoxicology

Hye Min Kang, Chang Bum Jeong, Young Hwan Lee, Yan Hong Cui, Duck Hyun Kim, Min Chul Lee, Hui Su Kim, Jeonghoon Han, Dae Sik Hwang, Su Jae Lee, Jae Seong Lee

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The mitogen-activated protein kinases (MAPKs) family is known to mediate various biological processes in response to diverse environmental pollutants. Although MAPKs are well characterized and studied in vertebrates, in invertebrates the cross-reactivities of MAPKs antibodies were not clearly known in response to environmental pollutants due to limited information of antibody epitopes with material resources for invertebrates. In this paper, we performed phylogenetic analysis of MAPKs genes in the marine rotifer Brachionus koreanus and the copepods Paracyclopina nana and Tigriopus japonicus. Also in rotifer and copepods, several studies of Western blot of MAPK signaling pathways were shown in response to environmental pollutants, including multi-walled carbon nanotubes (MWCNTs), water-accommodated fractions (WAFs) of crude oil, and microplastics. This paper will provide a better understanding of the underlying mechanistic scenario in terms of cross-reactivities of mammalian antibodies in rotifer and copepod.

Original languageEnglish
Pages (from-to)614-623
Number of pages10
JournalMarine Pollution Bulletin
Volume124
Issue number2
DOIs
StatePublished - 2017 Nov 30

Keywords

  • Copepod
  • Ecotoxicology
  • MAPKs
  • Rotifer
  • Signal transduction

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