CPP Applications in Immune Modulation and Disease Therapy

Ja Hyun Koo, Won Ju Kim, Je Min Choi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

About 30 years ago, the discovery of CPP improved the therapeutic approach to treat diseases and extended the range of potential targets to intracellular molecules. There are potential drug candidates for FDA approval based on active studies in basic research, preclinical, and clinical trials. Various attempts by CPP application to control the diseases such as allergy, autoimmunity, cancer, and infection demonstrated a strategy to make a new drug pipeline for successful discovery of a biologic drug for immune modulation. However, there are still no CPP-based drug candidates for immune-related diseases in the clinical stage. To control immune responses successfully, not only increasing delivery efficiency of CPPs but also selecting potential target cells and cargoes could be important issues. In particular, as it becomes possible to control intracellular targets, efforts to find various novel potential target are being attempted. In this chapter, we focused on CPP-based approaches to treat diseases through modulation of immune responses and discussed for perspectives on future direction of the research for successful application of CPP technology to immune modulation and disease therapy in clinical trial.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages347-368
Number of pages22
DOIs
StatePublished - 2022
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume2383
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Allergy
  • Autoimmune disease
  • Cancer
  • Clinical trials
  • Disease therapy
  • Immune cells
  • Immune modulation
  • Neurological disease
  • Vaccine

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