Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical type

Sang Won Seo, Jaewon Ahn, Uicheul Yoon, Kiho Im, Jong-Min Lee, Sung Tae Kim, Hyun Jung Ahn, Juhee Chin, Yong Jeong, Duk L. Na

Research output: Contribution to journalArticle

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Abstract

Background and Purpose Amnestic mild cognitive impairment (MCI) is known to be a preclinical stage of Alzheimer's disease (AD). Similarly, MCI associated with small-vessel disease (svMCI), might be a forme froste of subcortical vascular dementia (SVaD). Patterns of cortical thinning in addition to the ischemia rating on MRI may further elucidate the clinical characteristics and pathogenesis of SVaD and svMCI. We tried to determine if svMCI differs from SVaD in the distribution of cortical atrophy, which may help understand the hierarchy between svMCI and SVaD and possibly also how svMCI evolves into SVaD. METHODS Twenty patients with SVaD, 34 patients with svMCI, 115 patients with AD, and 96 individuals with normal-cognition (NC) were imaged with magnetic resonance imaging (MRI) including 3-dimensional volumetric images for cortical thickness analysis across the entire brain. RESULTS Compared to NC, svMCI patients showed cortical thinning in inferior frontal and orbitofrontal gyri, anterior cingulate, insula, superior temporal gyrus, and lingual gyrus, while cortical thinning in SVaD patients involved all these areas plus dorsolateral prefrontal and temporal cortices. Conclusion Our findings suggest the presence of hierarchy between svMCI and SVaD, and that the cognitive decline from svMCI to SVaD is associated with lesions in dorsolateral prefrontal and temporal cortices.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalJournal of Neuroimaging
Volume20
Issue number1
DOIs
StatePublished - 2010 Jan 1

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Vascular Dementia
Blood Vessels
Prefrontal Cortex
Temporal Lobe
Cognition
Alzheimer Disease
Magnetic Resonance Imaging
Cognitive Dysfunction
Occipital Lobe
Gyrus Cinguli
Atrophy
Ischemia

Keywords

  • Cortical thinning
  • Dementia
  • Mild cognitive impairment
  • Small-vessel disease

Cite this

Seo, Sang Won ; Ahn, Jaewon ; Yoon, Uicheul ; Im, Kiho ; Lee, Jong-Min ; Tae Kim, Sung ; Ahn, Hyun Jung ; Chin, Juhee ; Jeong, Yong ; Na, Duk L. / Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical type. In: Journal of Neuroimaging. 2010 ; Vol. 20, No. 1. pp. 37-45.
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Seo, SW, Ahn, J, Yoon, U, Im, K, Lee, J-M, Tae Kim, S, Ahn, HJ, Chin, J, Jeong, Y & Na, DL 2010, 'Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical type', Journal of Neuroimaging, vol. 20, no. 1, pp. 37-45. https://doi.org/10.1111/j.1552-6569.2008.00293.x

Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical type. / Seo, Sang Won; Ahn, Jaewon; Yoon, Uicheul; Im, Kiho; Lee, Jong-Min; Tae Kim, Sung; Ahn, Hyun Jung; Chin, Juhee; Jeong, Yong; Na, Duk L.

In: Journal of Neuroimaging, Vol. 20, No. 1, 01.01.2010, p. 37-45.

Research output: Contribution to journalArticle

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AU - Tae Kim, Sung

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AU - Na, Duk L.

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N2 - Background and Purpose Amnestic mild cognitive impairment (MCI) is known to be a preclinical stage of Alzheimer's disease (AD). Similarly, MCI associated with small-vessel disease (svMCI), might be a forme froste of subcortical vascular dementia (SVaD). Patterns of cortical thinning in addition to the ischemia rating on MRI may further elucidate the clinical characteristics and pathogenesis of SVaD and svMCI. We tried to determine if svMCI differs from SVaD in the distribution of cortical atrophy, which may help understand the hierarchy between svMCI and SVaD and possibly also how svMCI evolves into SVaD. METHODS Twenty patients with SVaD, 34 patients with svMCI, 115 patients with AD, and 96 individuals with normal-cognition (NC) were imaged with magnetic resonance imaging (MRI) including 3-dimensional volumetric images for cortical thickness analysis across the entire brain. RESULTS Compared to NC, svMCI patients showed cortical thinning in inferior frontal and orbitofrontal gyri, anterior cingulate, insula, superior temporal gyrus, and lingual gyrus, while cortical thinning in SVaD patients involved all these areas plus dorsolateral prefrontal and temporal cortices. Conclusion Our findings suggest the presence of hierarchy between svMCI and SVaD, and that the cognitive decline from svMCI to SVaD is associated with lesions in dorsolateral prefrontal and temporal cortices.

AB - Background and Purpose Amnestic mild cognitive impairment (MCI) is known to be a preclinical stage of Alzheimer's disease (AD). Similarly, MCI associated with small-vessel disease (svMCI), might be a forme froste of subcortical vascular dementia (SVaD). Patterns of cortical thinning in addition to the ischemia rating on MRI may further elucidate the clinical characteristics and pathogenesis of SVaD and svMCI. We tried to determine if svMCI differs from SVaD in the distribution of cortical atrophy, which may help understand the hierarchy between svMCI and SVaD and possibly also how svMCI evolves into SVaD. METHODS Twenty patients with SVaD, 34 patients with svMCI, 115 patients with AD, and 96 individuals with normal-cognition (NC) were imaged with magnetic resonance imaging (MRI) including 3-dimensional volumetric images for cortical thickness analysis across the entire brain. RESULTS Compared to NC, svMCI patients showed cortical thinning in inferior frontal and orbitofrontal gyri, anterior cingulate, insula, superior temporal gyrus, and lingual gyrus, while cortical thinning in SVaD patients involved all these areas plus dorsolateral prefrontal and temporal cortices. Conclusion Our findings suggest the presence of hierarchy between svMCI and SVaD, and that the cognitive decline from svMCI to SVaD is associated with lesions in dorsolateral prefrontal and temporal cortices.

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