Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer

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Abstract

Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and18F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelation of uptake of each tracer with prognostic factors and tumor molecular subtypes. A total of 96 patients with invasive ductal carcinoma who underwent preoperative breast-specific gamma imaging and FDG positron-emission tomography/computed tomography were retrospectively enrolled. Tumor-to-background ratio (TBR) of sestamibi and maximum standardized uptake value (SUVmax) of FDG were correlated with each other. Each of them was then compared with prognostic factors and molecular subtypes. In all tumors, there was a moderate positive correlation between TBR and SUVmax (r = 0.520, P <.001). Both TBR and SUVmax were significantly correlated with tumor size, incidence of axillary lymph node metastasis, histologic grade, estrogen receptor, progesterone receptor status, and Ki-67. There is a moderate degree of association between TBR of sestamibi and SUVmax of FDG in the invasive breast cancer. Two imaging indexes showed the similar tendency related with prognostic factors and molecular subtypes. While both TBR and SUVmax were significantly different between luminal A and nonluminal A tumors, neither of them had high enough sensitivity or specificity to obviate pathologic and molecular diagnosis.

Original languageEnglish
Article numbere12840
JournalMedicine (United States)
Volume97
Issue number43
DOIs
StatePublished - 2018 Oct 1

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Breast
Breast Neoplasms
Neoplasms
Ductal Carcinoma
Progesterone Receptors
Estrogen Receptors
Lymph Nodes
Neoplasm Metastasis
Sensitivity and Specificity
Incidence

Keywords

  • Breast cancer
  • Breast-specific gamma imaging
  • Breast-specific gamma imaging
  • Fluorodeoxyglucose
  • Technetium-99m sesta-methoxyisobutylisonitrile

Cite this

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title = "Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer",
abstract = "Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and18F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelation of uptake of each tracer with prognostic factors and tumor molecular subtypes. A total of 96 patients with invasive ductal carcinoma who underwent preoperative breast-specific gamma imaging and FDG positron-emission tomography/computed tomography were retrospectively enrolled. Tumor-to-background ratio (TBR) of sestamibi and maximum standardized uptake value (SUVmax) of FDG were correlated with each other. Each of them was then compared with prognostic factors and molecular subtypes. In all tumors, there was a moderate positive correlation between TBR and SUVmax (r = 0.520, P <.001). Both TBR and SUVmax were significantly correlated with tumor size, incidence of axillary lymph node metastasis, histologic grade, estrogen receptor, progesterone receptor status, and Ki-67. There is a moderate degree of association between TBR of sestamibi and SUVmax of FDG in the invasive breast cancer. Two imaging indexes showed the similar tendency related with prognostic factors and molecular subtypes. While both TBR and SUVmax were significantly different between luminal A and nonluminal A tumors, neither of them had high enough sensitivity or specificity to obviate pathologic and molecular diagnosis.",
keywords = "Breast cancer, Breast-specific gamma imaging, Breast-specific gamma imaging, Fluorodeoxyglucose, Technetium-99m sesta-methoxyisobutylisonitrile",
author = "Lee, {Soo Jin} and Chung, {Min Sung} and Su-Jin Shin and Choi, {Yun Young}",
year = "2018",
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doi = "10.1097/MD.0000000000012840",
language = "English",
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journal = "Medicine",
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T1 - Correlation of tumor uptake on breast-specific gamma imaging and fluorodeoxyglucose PET/CT with molecular subtypes of breast cancer

AU - Lee, Soo Jin

AU - Chung, Min Sung

AU - Shin, Su-Jin

AU - Choi, Yun Young

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and18F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelation of uptake of each tracer with prognostic factors and tumor molecular subtypes. A total of 96 patients with invasive ductal carcinoma who underwent preoperative breast-specific gamma imaging and FDG positron-emission tomography/computed tomography were retrospectively enrolled. Tumor-to-background ratio (TBR) of sestamibi and maximum standardized uptake value (SUVmax) of FDG were correlated with each other. Each of them was then compared with prognostic factors and molecular subtypes. In all tumors, there was a moderate positive correlation between TBR and SUVmax (r = 0.520, P <.001). Both TBR and SUVmax were significantly correlated with tumor size, incidence of axillary lymph node metastasis, histologic grade, estrogen receptor, progesterone receptor status, and Ki-67. There is a moderate degree of association between TBR of sestamibi and SUVmax of FDG in the invasive breast cancer. Two imaging indexes showed the similar tendency related with prognostic factors and molecular subtypes. While both TBR and SUVmax were significantly different between luminal A and nonluminal A tumors, neither of them had high enough sensitivity or specificity to obviate pathologic and molecular diagnosis.

AB - Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and18F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelation of uptake of each tracer with prognostic factors and tumor molecular subtypes. A total of 96 patients with invasive ductal carcinoma who underwent preoperative breast-specific gamma imaging and FDG positron-emission tomography/computed tomography were retrospectively enrolled. Tumor-to-background ratio (TBR) of sestamibi and maximum standardized uptake value (SUVmax) of FDG were correlated with each other. Each of them was then compared with prognostic factors and molecular subtypes. In all tumors, there was a moderate positive correlation between TBR and SUVmax (r = 0.520, P <.001). Both TBR and SUVmax were significantly correlated with tumor size, incidence of axillary lymph node metastasis, histologic grade, estrogen receptor, progesterone receptor status, and Ki-67. There is a moderate degree of association between TBR of sestamibi and SUVmax of FDG in the invasive breast cancer. Two imaging indexes showed the similar tendency related with prognostic factors and molecular subtypes. While both TBR and SUVmax were significantly different between luminal A and nonluminal A tumors, neither of them had high enough sensitivity or specificity to obviate pathologic and molecular diagnosis.

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KW - Breast-specific gamma imaging

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