Controlled release of riboflavin and insulin through crosslinked poly(vinyl alcohol)/chitosan blend membrane

Jin Hong Kim, Ju Young Kim, Young Moo Lee, Kea Yong Kim

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

The permeation of riboflavin and insulin through poly(vinyl alcohol) (PVA) and chitosan blend membrane was conducted. The permeability coefficients of both solutes through the crosslinked PVA and chitosan blend membrane were in the order of 10−6−10−7 cm3 cm/cm2s and showed a pH dependence. The pH‐dependent permeation behavior was discussed in terms of water content and water structure inside of the swollen membrane. Riboflavin and insulin were presumed to permeate through the free water region in the swollen blend membrane. The DSC thermograms of these membranes indicated that the content of free water and the amount of freezing bound water increased with the water content in the membrane. The greater permeation rate of solutes in acidic solution rather than in neutral solution was due to an increase in both water content and the amount of free water and freezing bound water.

Original languageEnglish
Pages (from-to)1823-1828
Number of pages6
JournalJournal of Applied Polymer Science
Volume44
Issue number10
DOIs
StatePublished - 1992 Apr 5

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