Comparison of the clinical characteristics of community-acquired acute pyelonephritis between male and female patients

Wooyoung Jang, Hyun uk Jo, Bongyoung Kim, Ki Tae Kwon, Seong yeol Ryu, Seong Heon Wie, Jieun Kim, Se Yoon Park, Kyung Wook Hong, Hye In Kim, Hyun ah Kim, Mi Hee Kim, Mi Hyun Bae, Yong Hak Sohn, Yangsoon Lee, Hyunjoo Pai

Research output: Contribution to journalArticlepeer-review


Background: Community-acquired acute pyelonephritis (CA-APN) is relatively rare in men. This study aimed to compare the clinical characteristics of CA-APN between male and female patients. Methods: We prospectively collected the clinical and microbiological data of hospitalized CA-APN patients aged ≥19 years in South Korea from March 2010 to February 2011 in 11 hospitals and from September 2017 to August 2018 in 8 hospitals. Only the first episodes of APN of each patient during the study period were included. Results: From 2010 to 2011, 573 patients from 11 hospitals were recruited, and from 2017 to 2018, 340 patients were recruited from 8 hospitals. Among them, 5.9% (54/913) were male. Male patients were older (66.0 ± 15.2 vs. 55.3 ± 19.0 years, P < 0.001), had a higher Charlson comorbidity index (1.3 ± 1.5 vs. 0.7 ± 1.2, P = 0.027), and had a higher proportion of structural problems in the urinary tract (40.7% vs. 6.1%, P < 0.001) than female patients. Moreover, the total duration of antibiotic treatment was longer (21.8 ± 17.8 d vs. 17.3 ± 9.4 d, P = 0.001) and the proportion of carbapenem usage was higher (24.1% vs. 9.5%, P = 0.001) in men than in women. Male patients were hospitalized for longer durations than female patients (median, 10 d vs. 7 d, P < 0.001). Conclusions: Male CA-APN patients were older and had more comorbidities than female CA-APN patients. In addition, male patients received antibiotic treatment for a longer duration than female patients.

Original languageEnglish
Pages (from-to)1013-1019
Number of pages7
JournalJournal of Infection and Chemotherapy
Issue number7
StatePublished - 2021 Jul


  • Korea
  • Male
  • Pyelonephritis
  • Urinary tract infection


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