Comparison of ramosetron's and ondansetron's preventive anti-emetic effects in highly susceptible patients undergoing abdominal hysterectomy

Jae Woo Lee, Hyejin Park, Juyoun Choi, So Jin Park, Hyoseok Kang, Eugene Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: This study compared the preventive effects of ramosetron and ondansetron on postoperative nausea and vomiting (PONV) in highly susceptible patients undergoing abdominal hysterectomy. Methods: In a prospective, randomized, double-blinded study, a total of 120 highly susceptible women (nonsmokers, those receiving opioid-based IV patient-controlled analgesia [PCA]) undergoing abdominal hysterectomy were included in the study. Patients were divided into 2 groups and each group received either 0.3 mg of ramosetron or 4 mg of ondansetron, IV. All patients received fentanyl-based IV PCA during the 48 h postoperative periods. The incidences of PONV and side effects of 5-HT3 antagonists (headache and dizziness) were assessed at 3 intervals (<2 h, 2-24 h and 24-48 h) postoperatively. Results: Patients in the ramosetron group showed a significantly higher ratio of complete response and lower incidence of nausea during the 24-48 h interval after surgery compared with those the ondansetron group. Conclusions: Ramosetron (0.3 mg) is more effective in preventing delayed PONV in highly susceptible women undergoing abdominal hysterectomy compared with ondansetron (4 mg).

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalKorean Journal of Anesthesiology
Volume61
Issue number6
DOIs
StatePublished - 2011 Jan 1

Fingerprint

Ondansetron
Antiemetics
Hysterectomy
Postoperative Nausea and Vomiting
Patient-Controlled Analgesia
Serotonin 5-HT3 Receptor Antagonists
Incidence
Dizziness
Fentanyl
Postoperative Period
Nausea
Opioid Analgesics
Headache
ramosetron

Keywords

  • Abdominal hysterectomy
  • Ondansetron
  • PONV
  • Ramosetron

Cite this

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abstract = "Background: This study compared the preventive effects of ramosetron and ondansetron on postoperative nausea and vomiting (PONV) in highly susceptible patients undergoing abdominal hysterectomy. Methods: In a prospective, randomized, double-blinded study, a total of 120 highly susceptible women (nonsmokers, those receiving opioid-based IV patient-controlled analgesia [PCA]) undergoing abdominal hysterectomy were included in the study. Patients were divided into 2 groups and each group received either 0.3 mg of ramosetron or 4 mg of ondansetron, IV. All patients received fentanyl-based IV PCA during the 48 h postoperative periods. The incidences of PONV and side effects of 5-HT3 antagonists (headache and dizziness) were assessed at 3 intervals (<2 h, 2-24 h and 24-48 h) postoperatively. Results: Patients in the ramosetron group showed a significantly higher ratio of complete response and lower incidence of nausea during the 24-48 h interval after surgery compared with those the ondansetron group. Conclusions: Ramosetron (0.3 mg) is more effective in preventing delayed PONV in highly susceptible women undergoing abdominal hysterectomy compared with ondansetron (4 mg).",
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Comparison of ramosetron's and ondansetron's preventive anti-emetic effects in highly susceptible patients undergoing abdominal hysterectomy. / Lee, Jae Woo; Park, Hyejin; Choi, Juyoun; Park, So Jin; Kang, Hyoseok; Kim, Eugene.

In: Korean Journal of Anesthesiology, Vol. 61, No. 6, 01.01.2011, p. 488-492.

Research output: Contribution to journalArticle

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