Comparison of gas exchange parameters between same volume of N 2 -O 2 and heliox inhalation

Won Sohn Jang, C. M. Lim, Y. Koh, Deog Lee Jong Deog Lee, Do Lee Sang Do Lee, Sung Kim Woo Sung Kim, Soon Kim Dong Soon Kim, Dong Kim Won Dong Kim

Research output: Contribution to journalArticle

Abstract

Background: Heliox is known to decrease PaCO 2 in patients with increased airway resistance by increasing minute ventilation and reducing work of breathing (WOB). Besides these effect, heliox is expected to decrease functional anatomic dead space owing to improvement of peak expiratory flow rate (PEFR) and enhancement of gas distribution. We investigated whether heliox can decrease PaCO 2 even at the same minute ventilation (VE) and WOB with N 2 -O 2 to speculate the effect of the heliox on the anatomic dead space. Material and Method: The subjects were 8 mechanically ventilated patients with asthma or upper airway obstruction (M:F = 5:3, 68 ± 10 years) who were under neuromuscular paralysis. The study was consisted of three 15- minutes phases: basal N 2 -O 2 , heliox and washout. Heliox was administered via the low pressure inlet of servo 900C, and respiratory parameters were measured by pulmonary monitor (CP-100 pulmonary monitor, Bicore, Irvine, CA, USA). To obtain the same tidal volume (Vt) in heliox phase, the Vt on monitor was adjusted by the factor of relative flow rate of heliox to N 2 -O 2 . Dead space was calculated by Bohr equation. Results: 1) Vt, VE, peak inspiratory pressure(PIP) and peak inspiratory flow rate (PIFR) were not different between N 2 -O 2 and heliox. 2) PEFR was higher on heliox (0.52 ± 0.19 L/sec) than N 2 -O 2 (0.44 ± 0.13 L/sec) (p = 0.024). 3) PaCO 2 (mmHg) were decreased with heliox (56.1 ± 14.1) compared to N 2 -O 2 (60.5 ± 15.9) (p = 0.027), 4) Dead space ventilation (%) were decreased with heliox (73 ± 9 with N 2 -O 2 and 71 ± 10 with heliox) (p = 0.026). Conclusion: Heliox decreased PaCO 2 even at the same VE and WOB with N 2 O 2 and the effect was considered to be related with the reduction of anatomic dead space.

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalTuberculosis and Respiratory Diseases
Volume45
Issue number1
DOIs
StatePublished - 1998 Jan 1

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Inhalation
Gases
Ventilation
Work of Breathing
Peak Expiratory Flow Rate
heliox
Pressure
Lung
Airway Resistance
Tidal Volume
Airway Obstruction
Paralysis
Asthma

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Jang, W. S., Lim, C. M., Koh, Y., Jong Deog Lee, D. L., Sang Do Lee, D. L., Woo Sung Kim, S. K., ... Won Dong Kim, D. K. (1998). Comparison of gas exchange parameters between same volume of N 2 -O 2 and heliox inhalation Tuberculosis and Respiratory Diseases, 45(1), 169-175. https://doi.org/10.4046/trd.1998.45.1.169
Jang, Won Sohn ; Lim, C. M. ; Koh, Y. ; Jong Deog Lee, Deog Lee ; Sang Do Lee, Do Lee ; Woo Sung Kim, Sung Kim ; Dong Soon Kim, Soon Kim ; Won Dong Kim, Dong Kim. / Comparison of gas exchange parameters between same volume of N 2 -O 2 and heliox inhalation In: Tuberculosis and Respiratory Diseases. 1998 ; Vol. 45, No. 1. pp. 169-175.
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abstract = "Background: Heliox is known to decrease PaCO 2 in patients with increased airway resistance by increasing minute ventilation and reducing work of breathing (WOB). Besides these effect, heliox is expected to decrease functional anatomic dead space owing to improvement of peak expiratory flow rate (PEFR) and enhancement of gas distribution. We investigated whether heliox can decrease PaCO 2 even at the same minute ventilation (VE) and WOB with N 2 -O 2 to speculate the effect of the heliox on the anatomic dead space. Material and Method: The subjects were 8 mechanically ventilated patients with asthma or upper airway obstruction (M:F = 5:3, 68 ± 10 years) who were under neuromuscular paralysis. The study was consisted of three 15- minutes phases: basal N 2 -O 2 , heliox and washout. Heliox was administered via the low pressure inlet of servo 900C, and respiratory parameters were measured by pulmonary monitor (CP-100 pulmonary monitor, Bicore, Irvine, CA, USA). To obtain the same tidal volume (Vt) in heliox phase, the Vt on monitor was adjusted by the factor of relative flow rate of heliox to N 2 -O 2 . Dead space was calculated by Bohr equation. Results: 1) Vt, VE, peak inspiratory pressure(PIP) and peak inspiratory flow rate (PIFR) were not different between N 2 -O 2 and heliox. 2) PEFR was higher on heliox (0.52 ± 0.19 L/sec) than N 2 -O 2 (0.44 ± 0.13 L/sec) (p = 0.024). 3) PaCO 2 (mmHg) were decreased with heliox (56.1 ± 14.1) compared to N 2 -O 2 (60.5 ± 15.9) (p = 0.027), 4) Dead space ventilation ({\%}) were decreased with heliox (73 ± 9 with N 2 -O 2 and 71 ± 10 with heliox) (p = 0.026). Conclusion: Heliox decreased PaCO 2 even at the same VE and WOB with N 2 O 2 and the effect was considered to be related with the reduction of anatomic dead space.",
author = "Jang, {Won Sohn} and Lim, {C. M.} and Y. Koh and {Jong Deog Lee}, {Deog Lee} and {Sang Do Lee}, {Do Lee} and {Woo Sung Kim}, {Sung Kim} and {Dong Soon Kim}, {Soon Kim} and {Won Dong Kim}, {Dong Kim}",
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Jang, WS, Lim, CM, Koh, Y, Jong Deog Lee, DL, Sang Do Lee, DL, Woo Sung Kim, SK, Dong Soon Kim, SK & Won Dong Kim, DK 1998, ' Comparison of gas exchange parameters between same volume of N 2 -O 2 and heliox inhalation ', Tuberculosis and Respiratory Diseases, vol. 45, no. 1, pp. 169-175. https://doi.org/10.4046/trd.1998.45.1.169

Comparison of gas exchange parameters between same volume of N 2 -O 2 and heliox inhalation . / Jang, Won Sohn; Lim, C. M.; Koh, Y.; Jong Deog Lee, Deog Lee; Sang Do Lee, Do Lee; Woo Sung Kim, Sung Kim; Dong Soon Kim, Soon Kim; Won Dong Kim, Dong Kim.

In: Tuberculosis and Respiratory Diseases, Vol. 45, No. 1, 01.01.1998, p. 169-175.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of gas exchange parameters between same volume of N 2 -O 2 and heliox inhalation

AU - Jang, Won Sohn

AU - Lim, C. M.

AU - Koh, Y.

AU - Jong Deog Lee, Deog Lee

AU - Sang Do Lee, Do Lee

AU - Woo Sung Kim, Sung Kim

AU - Dong Soon Kim, Soon Kim

AU - Won Dong Kim, Dong Kim

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Background: Heliox is known to decrease PaCO 2 in patients with increased airway resistance by increasing minute ventilation and reducing work of breathing (WOB). Besides these effect, heliox is expected to decrease functional anatomic dead space owing to improvement of peak expiratory flow rate (PEFR) and enhancement of gas distribution. We investigated whether heliox can decrease PaCO 2 even at the same minute ventilation (VE) and WOB with N 2 -O 2 to speculate the effect of the heliox on the anatomic dead space. Material and Method: The subjects were 8 mechanically ventilated patients with asthma or upper airway obstruction (M:F = 5:3, 68 ± 10 years) who were under neuromuscular paralysis. The study was consisted of three 15- minutes phases: basal N 2 -O 2 , heliox and washout. Heliox was administered via the low pressure inlet of servo 900C, and respiratory parameters were measured by pulmonary monitor (CP-100 pulmonary monitor, Bicore, Irvine, CA, USA). To obtain the same tidal volume (Vt) in heliox phase, the Vt on monitor was adjusted by the factor of relative flow rate of heliox to N 2 -O 2 . Dead space was calculated by Bohr equation. Results: 1) Vt, VE, peak inspiratory pressure(PIP) and peak inspiratory flow rate (PIFR) were not different between N 2 -O 2 and heliox. 2) PEFR was higher on heliox (0.52 ± 0.19 L/sec) than N 2 -O 2 (0.44 ± 0.13 L/sec) (p = 0.024). 3) PaCO 2 (mmHg) were decreased with heliox (56.1 ± 14.1) compared to N 2 -O 2 (60.5 ± 15.9) (p = 0.027), 4) Dead space ventilation (%) were decreased with heliox (73 ± 9 with N 2 -O 2 and 71 ± 10 with heliox) (p = 0.026). Conclusion: Heliox decreased PaCO 2 even at the same VE and WOB with N 2 O 2 and the effect was considered to be related with the reduction of anatomic dead space.

AB - Background: Heliox is known to decrease PaCO 2 in patients with increased airway resistance by increasing minute ventilation and reducing work of breathing (WOB). Besides these effect, heliox is expected to decrease functional anatomic dead space owing to improvement of peak expiratory flow rate (PEFR) and enhancement of gas distribution. We investigated whether heliox can decrease PaCO 2 even at the same minute ventilation (VE) and WOB with N 2 -O 2 to speculate the effect of the heliox on the anatomic dead space. Material and Method: The subjects were 8 mechanically ventilated patients with asthma or upper airway obstruction (M:F = 5:3, 68 ± 10 years) who were under neuromuscular paralysis. The study was consisted of three 15- minutes phases: basal N 2 -O 2 , heliox and washout. Heliox was administered via the low pressure inlet of servo 900C, and respiratory parameters were measured by pulmonary monitor (CP-100 pulmonary monitor, Bicore, Irvine, CA, USA). To obtain the same tidal volume (Vt) in heliox phase, the Vt on monitor was adjusted by the factor of relative flow rate of heliox to N 2 -O 2 . Dead space was calculated by Bohr equation. Results: 1) Vt, VE, peak inspiratory pressure(PIP) and peak inspiratory flow rate (PIFR) were not different between N 2 -O 2 and heliox. 2) PEFR was higher on heliox (0.52 ± 0.19 L/sec) than N 2 -O 2 (0.44 ± 0.13 L/sec) (p = 0.024). 3) PaCO 2 (mmHg) were decreased with heliox (56.1 ± 14.1) compared to N 2 -O 2 (60.5 ± 15.9) (p = 0.027), 4) Dead space ventilation (%) were decreased with heliox (73 ± 9 with N 2 -O 2 and 71 ± 10 with heliox) (p = 0.026). Conclusion: Heliox decreased PaCO 2 even at the same VE and WOB with N 2 O 2 and the effect was considered to be related with the reduction of anatomic dead space.

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DO - 10.4046/trd.1998.45.1.169

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