The paper aims to develop fragility curves for old reinforced concrete (RC) frames by accounting for their potential failure modes, particularly shear failure of columns and beam-column connections. For this purpose, the analytical models capturing column nonlinear flexure-shear behavior and joint shear behavior are compared with experimental results available in the literature for the validation. Accordingly, to investigate the effect of joint and column shear failure behaviors on frames, a four-story, three-bay ordinary moment frame, one of typical older RC office buildings in California, was selected in this paper. For the subject frame, three types of analytical frame models are taken into account in order to examine its potential failure responses: (1) joint shear, (2) column shear, and (3) joint and column shears. Fragility curves are developed for three frame models and the probability of exceeding a damage state is computed to compare the seismic vulnerability of those frame models.