Combined extract of leonurus japonicus houtt, eclipta prostrata l., and pueraria lobata ohwi improved hot flashes and depression in an ovariectomized rat model of menopause

Eun Young Kang, Hyun Kyung Kim, Ji Yeon Jung, Ji Hyun Kim, Tan Kyung Woo, Jeong In Choi, Jong Hoon Kim, Changwon Ahn, Hyeon Gyu Lee, Gwang Woong Go

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Menopause leads to ovarian hormone loss, which causes symptoms such as weight gain, hot flashes, and depression. Exploring nutraceuticals is important for treating menopausal symptoms that extensively impact women’s quality of life. We hypothesized that a combination of Leonurus japonicus Houtt, Eclipta prostrata L., and Pueraria lobata Ohwi (LEPE) would alleviate menopausal symptoms in an ovariectomized menopausal rat model. Bilateral ovariectomy was performed and animals were assigned to five groups: (1) Sham, (2) Vehicle, (-) Control, (3) LEPE (100 mg/kg bw), (4) LEPE (200 mg/kg bw), and (5) Estradiol (3 µg/kg bw). LEPE was orally administered daily for 12 weeks. LEPE supplementation did not affect growth performance (body weight and feed intake) or body composition (lean mass and fat in tissue). LEPE did not cause deviations in aspartate amino-transferase, alanine aminotransferase, estradiol, and follicle-stimulating hormone levels, indicating no hepatotoxicity or endocrine disturbance. LEPE decreased type I collagen (CTX-1) but did not affect bone mineral density or osteocalcin. LEPE decreased tail temperature and increased rectal temperature, improving menopause-related vasomotor symptoms. Furthermore, LEPE ameliorated depression-related behavior, including in forced swimming and tail suspension tests. Thus, LEPE may improve menopausal symptoms by enhancing vasomotor symptoms and depression in an ovariectomized rat menopause model.

Original languageEnglish
Article number180
JournalFoods
Volume10
Issue number1
DOIs
StatePublished - 2021 Jan

Keywords

  • Eclipta prostrata L
  • Hot flashes
  • Leonurus japonicus Houtt
  • Menopausal depression
  • Pueraria lobata Ohwi

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