Cognitive impairment is associated with elevated serum homocysteine levels among older adults

Sunghee Kim, Bo Youl Choi, Jung Hyun Nam, Mi Kyung Kim, Dong Hoon Oh, Yoon Jung Yang

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: The aim of this study was to examine the associations between the risk of cognitive impairment and the serum levels of folate, vitamin B 12 , and homocysteine (Hcy). Methods: Subjects were persons aged 60–79 years who participated in the Yangpyeong Cohort study between 2011 and 2012. Cognitive impairment and normal subjects consisted of 100 pairs of old adults matched by age, sex, and education levels. Cognitive function was evaluated with the Korean version of the Mini-Mental State Examination for Dementia Screening (MMSE-DS). Pearson’s partial correlation coefficients and conditional multiple logistic regression analysis were applied to determine the associations between cognitive function and the serum levels of folate, vitamin B 12 , and Hcy. Results: Compared with the matched normal group, the cognitive impairment group had higher proportions of folate deficiency (< 3 ng/mL) and hyperhomocysteinemia (≥ 15 µmol/L). Serum Hcy concentrations were inversely associated with serum folate (r = − 0.234, p = 0.001) and MMSE-DS score (r = − 0.150, p = 0.037) after adjusting for age, sex, and education. The high Hcy group showed a higher prevalence of cognitive impairment (4th vs. 1st quartile, OR 3.30, 95% CI 1.12–9.72, p for trend = 0.014) after adjusting for exercise. Conclusions: The present findings suggest a putative protective role of high serum folate and normal Hcy against cognitive impairment among older adults.

Original languageEnglish
Pages (from-to)399-408
Number of pages10
JournalEuropean Journal of Nutrition
Volume58
Issue number1
DOIs
StatePublished - 2019 Feb 1

Fingerprint

Homocysteine
Folic Acid
Serum
Sex Education
Vitamin B 12
Cognition
Dementia
Hyperhomocysteinemia
Cohort Studies
Research Design
Logistic Models
Regression Analysis
Cognitive Dysfunction

Keywords

  • Cognitive impairment
  • Folate
  • Homocysteine
  • Vitamin B

Cite this

Kim, Sunghee ; Choi, Bo Youl ; Nam, Jung Hyun ; Kim, Mi Kyung ; Oh, Dong Hoon ; Yang, Yoon Jung. / Cognitive impairment is associated with elevated serum homocysteine levels among older adults. In: European Journal of Nutrition. 2019 ; Vol. 58, No. 1. pp. 399-408.
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abstract = "Purpose: The aim of this study was to examine the associations between the risk of cognitive impairment and the serum levels of folate, vitamin B 12 , and homocysteine (Hcy). Methods: Subjects were persons aged 60–79 years who participated in the Yangpyeong Cohort study between 2011 and 2012. Cognitive impairment and normal subjects consisted of 100 pairs of old adults matched by age, sex, and education levels. Cognitive function was evaluated with the Korean version of the Mini-Mental State Examination for Dementia Screening (MMSE-DS). Pearson’s partial correlation coefficients and conditional multiple logistic regression analysis were applied to determine the associations between cognitive function and the serum levels of folate, vitamin B 12 , and Hcy. Results: Compared with the matched normal group, the cognitive impairment group had higher proportions of folate deficiency (< 3 ng/mL) and hyperhomocysteinemia (≥ 15 µmol/L). Serum Hcy concentrations were inversely associated with serum folate (r = − 0.234, p = 0.001) and MMSE-DS score (r = − 0.150, p = 0.037) after adjusting for age, sex, and education. The high Hcy group showed a higher prevalence of cognitive impairment (4th vs. 1st quartile, OR 3.30, 95{\%} CI 1.12–9.72, p for trend = 0.014) after adjusting for exercise. Conclusions: The present findings suggest a putative protective role of high serum folate and normal Hcy against cognitive impairment among older adults.",
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Cognitive impairment is associated with elevated serum homocysteine levels among older adults. / Kim, Sunghee; Choi, Bo Youl; Nam, Jung Hyun; Kim, Mi Kyung; Oh, Dong Hoon; Yang, Yoon Jung.

In: European Journal of Nutrition, Vol. 58, No. 1, 01.02.2019, p. 399-408.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Oh, Dong Hoon

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