CMC and dynamic properties of poly(VA-b-St) copolymer micelles for drug delivery

Guang Hua Li, Chang Gi Cho

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The polymeric micelles from amphiphilic block copolymer poly(vinyl alcohol-b-styrene) (poly(VA-b-St)) with different syndiotacticity of poly(vinyl alcohol) (PVA) block were prepared by dialysis against water. Critical micelle concentration (CMC) and dynamic properties of poly(VA-b-St) copolymeric micelles were investigated by fluorescence techniques. From the fluorescence emission spectrum measurements using pyrene as a fluorescence probe, the observed CMC value was in the range of 0.125-4.47 mg/L. The CMC value increased with decreasing the weight ratio of PS to PVA block and with increasing the syndiotacticity of PVA block. The rate of pyrene release was very slow for block copolymers containing PVA block with higher syndiotacticity, which indicates that their micelles have increased kinetic stability.

Original languageEnglish
Pages (from-to)1444-1447
Number of pages4
JournalKorean Journal of Chemical Engineering
Volume25
Issue number6
DOIs
StatePublished - 2008 Nov 1

Keywords

  • Critical micelle concentration
  • Kinetic stability
  • Micelle
  • Poly(VA-b-St)
  • Syndiotacticity

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