Clinical impact of forced vital capacity on exercise performance in patients with chronic obstructive pulmonary disease

Seong Mi Moon, Jun Hyeok Lim, Yun Soo Hong, Kyeong Cheol Shin, Chang Youl Lee, Do Jin Kim, Sang Haak Lee, Ki Suck Jung, Chang Hoon Lee, Kwang Ha Yoo, Hyun Lee, Hye Yun Park

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Forced vital capacity (FVC) has been suggested to be a good biomarker for decreased exercise performance in patients with chronic obstructive pulmonary disease (COPD). However, as FVC is highly correlated with forced expiratory volume in 1 second (FEV1), the relationship between FVC and exercise capacity should be assessed within the category of FEV1, i.e., COPD severity. However, this was not considered in previous studies. Thus, limited data are available on the association between reduced FVC and exercise capacity measured by 6-min walk distance (6MWD) based on COPD severity. Methods: We performed a cross-sectional study using data from the Korean COPD Subgroup Study (KOCOSS) cohort. We evaluated 1,386 patients with moderate (n=895) and severe-to-very severe (n=491) COPD. Reduced FVC was defined as FVC <80% predicted and short 6MWD as <350 m. Multivariable logistic regression was used to evaluate the association between reduced FVC and short 6MWD. Results: There were no significant differences in respiratory symptoms and quality of life between the patients with reduced FVC and those with preserved FVC. However, patients with reduced FVC had shorter 6MWD (30.5 cm in moderate and 34.5 cm in severe-to-very severe COPD) and higher BODE index scores than those with preserved FVC. The cubic spline model revealed 6MWD peaked around 93% predicted of FVC in moderate COPD, whereas FVC showed a positive association with 6MWD in severe-to-very severe COPD. Multivariable analyses showed that reduced FVC was significantly associated with short 6MWD in both moderate [adjusted odds ratio (aOR) =1.44, 95% confidence interval (CI): 1.03-2.02] and severe-to-very severe (adjusted OR =1.55, 95% CI: 1.01-2.40) COPD. Conclusions: Reduced FVC was significantly associated with shorter 6MWD in moderate-to-very severe COPD patients, suggesting that reduced FVC might be reflective of 6MWD-measured exercise capacity in moderate-to-very severe COPD.

Original languageEnglish
Pages (from-to)837-846
Number of pages10
JournalJournal of Thoracic Disease
Volume13
Issue number2
DOIs
StatePublished - 2021 Feb

Keywords

  • 6-min-walk test (6MWT)
  • Chronic obstructive pulmonary disease (COPD)
  • Forced vital capacity (FVC)

Fingerprint

Dive into the research topics of 'Clinical impact of forced vital capacity on exercise performance in patients with chronic obstructive pulmonary disease'. Together they form a unique fingerprint.

Cite this