Clinical Impact of Extranodal Metabolic Tumor Volume in 240 Diffuse Large B cell Lymphoma Patients with Extranodal Involvement

Moo Kon Song, Joo Seop Chung, Sung Nam Lim, Won Sik Lee, Sang Min Lee, Seong Jang Kim, Hye Kyung Shim, Seok Mo Lee

Research output: Contribution to journalArticlepeer-review

Abstract

The present study is to investigate whether extranodal (EN) metabolic tumor volume (MTV) would have a specific clinical meaning for survival in EN diffuse large B cell lymphoma (DLBCL) patients. Two hundred forty DLBCL patients with EN involvement received 18F-fluorodeoxygenase (FDG) positron emission tomography/computed tomography (PET/CT) were enrolled. Survival analysis revealed that low EN MTV (PFS [progression-free survival], HR = 0.278, 95% CI = 0.127–0.807, p = 0.001; OS [overall survival], HR = 0.320, 95% CI = 0.145–0.703, p = 0.003), low total MTV (PFS, HR = 0.194, 95% CI = 0.085–0.445, p < 0.001; OS, HR = 0.213, 95% CI = 0.092–0.491, p < 0.007), and high National Cancer Center Network-International Prognostic Index score (PFS, HR = 3.152, 95% CI = 1.732–5.734, p < 0.001; OS, HR = 2.457, 95% CI = 1.363–4.430, p = 0.003) were independently associated with survivals in the patients. Our data showed that EN MTV is a useful and novel prognostic parameter for predicting survival in DLBCL patients with EN involvement.

Original languageEnglish
Pages (from-to)1221-1229
Number of pages9
JournalAnnals of Hematology
Volume100
Issue number5
DOIs
StatePublished - 2021 May
Externally publishedYes

Keywords

  • Extranodal involvement
  • Metabolic tumor volume
  • Positron emission tomography

Fingerprint

Dive into the research topics of 'Clinical Impact of Extranodal Metabolic Tumor Volume in 240 Diffuse Large B cell Lymphoma Patients with Extranodal Involvement'. Together they form a unique fingerprint.

Cite this