Clinical characteristics and psychotropic drug prescription patterns of bipolar disorder patients with a history of suicidal attempts

Findings from the REAP-BD, Korea

Seon Cheol Park, Kiwon Kim, Ok Jin Jang, Seung Gon Kim, Jung Goo Lee, Joon Hyuk Park, Joonho Choi, Dong Woo Lee, Shih Ku Lin, Chay Hoon Tan, Naotaka Shinfuku, Yong Chon Park

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Our study aimed to analyze the clinical characteristics and psychotropic prescription patterns of a history of suicide attempts in South Koreans with bipolar disorder (BD), by using only Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar disorder. The patterns of clinical characteristics and psychotropic drug use were compared among 53 patients with a history of suicide attempts and 297 without this history; the potential effects of confounding variables were adjusted with binary logistic analyses for discrete variables and analyses of covariance for continuous variables. After adjusting the effects of age, sex, duration of illness, and enrollment as an outpatient, patients with a history of suicide attempts were characterized by a significantly more prevalent depressive episode, lower prevalent remission state, lower levels of hemoglobin, and more use of antidepressants, anxiolytics, and hypnotics compared to those without lifetime suicide attempt. The inability to plan goal-directed behavior may be an intervening factor in the relationship between suicide attempts and depression in BD. Relatively low hemoglobin levels can be associated with manic episodes in patients with a history of suicide attempts and the use of antidepressants, anxiolytics, or hypnotics can be associated with suicide attempts in BD patients.

Original languageEnglish
Pages (from-to)459-463
Number of pages5
JournalPsychiatry Investigation
Volume16
Issue number6
DOIs
StatePublished - 2019 Jun 1

Fingerprint

Drug Prescriptions
Psychotropic Drugs
Korea
Bipolar Disorder
Suicide
Anti-Anxiety Agents
Hypnotics and Sedatives
Antidepressive Agents
Prescriptions
Hemoglobins
Confounding Factors (Epidemiology)
Outpatients
History
Depression
Research

Keywords

  • Antidepressant
  • Bipolar disorder
  • Depressive episode
  • Hemoglobin
  • Suicide attempt

Cite this

Park, Seon Cheol ; Kim, Kiwon ; Jang, Ok Jin ; Kim, Seung Gon ; Lee, Jung Goo ; Park, Joon Hyuk ; Choi, Joonho ; Lee, Dong Woo ; Lin, Shih Ku ; Tan, Chay Hoon ; Shinfuku, Naotaka ; Park, Yong Chon. / Clinical characteristics and psychotropic drug prescription patterns of bipolar disorder patients with a history of suicidal attempts : Findings from the REAP-BD, Korea. In: Psychiatry Investigation. 2019 ; Vol. 16, No. 6. pp. 459-463.
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abstract = "Our study aimed to analyze the clinical characteristics and psychotropic prescription patterns of a history of suicide attempts in South Koreans with bipolar disorder (BD), by using only Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar disorder. The patterns of clinical characteristics and psychotropic drug use were compared among 53 patients with a history of suicide attempts and 297 without this history; the potential effects of confounding variables were adjusted with binary logistic analyses for discrete variables and analyses of covariance for continuous variables. After adjusting the effects of age, sex, duration of illness, and enrollment as an outpatient, patients with a history of suicide attempts were characterized by a significantly more prevalent depressive episode, lower prevalent remission state, lower levels of hemoglobin, and more use of antidepressants, anxiolytics, and hypnotics compared to those without lifetime suicide attempt. The inability to plan goal-directed behavior may be an intervening factor in the relationship between suicide attempts and depression in BD. Relatively low hemoglobin levels can be associated with manic episodes in patients with a history of suicide attempts and the use of antidepressants, anxiolytics, or hypnotics can be associated with suicide attempts in BD patients.",
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Clinical characteristics and psychotropic drug prescription patterns of bipolar disorder patients with a history of suicidal attempts : Findings from the REAP-BD, Korea. / Park, Seon Cheol; Kim, Kiwon; Jang, Ok Jin; Kim, Seung Gon; Lee, Jung Goo; Park, Joon Hyuk; Choi, Joonho; Lee, Dong Woo; Lin, Shih Ku; Tan, Chay Hoon; Shinfuku, Naotaka; Park, Yong Chon.

In: Psychiatry Investigation, Vol. 16, No. 6, 01.06.2019, p. 459-463.

Research output: Contribution to journalArticleResearchpeer-review

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