Chronic lithium enhances hippocampal long-term potentiation, but not neurogenesis, in the aged rat dentate gyrus

In Tag Yu, Jin Seuk Kim, Sang-Hun Lee, Yong Sung Lee, Hyeon Son

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We investigated the hippocampal long-term potentiation (LTP), neurogenesis, and the activation of signaling molecules in the 20-month-old aged rats following chronic lithium treatment. Chronic lithium treatment produced a significant 79% increase in the numbers of BrdU(+) cells after treatment completion in the dentate gyrus (DG). Both LTP obtained from slices perfused with artificial cerebrospinal fluid (ACSF-LTP), and LTP recorded in the presence of bicuculline (bicuculline-LTP) were significantly greater in the lithium group than in the saline controls. Our results show that as with young rats, chronic lithium can substantially increase LTP and the number of BrdU(+) cells in the aged rats. However, neurogenesis, assessed by colocalization of NeuN and BrdU, was not detected in the aged rat DG subjected to chronic lithium treatment. Therefore, it is concluded that the increase in LTP and the number of BrdU(+) cells might not be associated with increases in neurogenesis in the granule cell layer of the DG. Lithium might has a beneficial effects through other signaling pathways in the aged brain.

Original languageEnglish
Pages (from-to)1193-1198
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume303
Issue number4
DOIs
StatePublished - 2003 Apr 18

Fingerprint

Long-Term Potentiation
Neurogenesis
Dentate Gyrus
Lithium
Rats
Bromodeoxyuridine
Bicuculline
Cell Count
Cerebrospinal fluid
Brain
Cerebrospinal Fluid
Chemical activation
Cells
Molecules

Keywords

  • Dentate gyrus
  • Lithium
  • Long-term potentiation
  • Neurogenesis
  • Rat
  • Synaptic plasticity

Cite this

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abstract = "We investigated the hippocampal long-term potentiation (LTP), neurogenesis, and the activation of signaling molecules in the 20-month-old aged rats following chronic lithium treatment. Chronic lithium treatment produced a significant 79{\%} increase in the numbers of BrdU(+) cells after treatment completion in the dentate gyrus (DG). Both LTP obtained from slices perfused with artificial cerebrospinal fluid (ACSF-LTP), and LTP recorded in the presence of bicuculline (bicuculline-LTP) were significantly greater in the lithium group than in the saline controls. Our results show that as with young rats, chronic lithium can substantially increase LTP and the number of BrdU(+) cells in the aged rats. However, neurogenesis, assessed by colocalization of NeuN and BrdU, was not detected in the aged rat DG subjected to chronic lithium treatment. Therefore, it is concluded that the increase in LTP and the number of BrdU(+) cells might not be associated with increases in neurogenesis in the granule cell layer of the DG. Lithium might has a beneficial effects through other signaling pathways in the aged brain.",
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Chronic lithium enhances hippocampal long-term potentiation, but not neurogenesis, in the aged rat dentate gyrus. / Yu, In Tag; Kim, Jin Seuk; Lee, Sang-Hun; Lee, Yong Sung; Son, Hyeon.

In: Biochemical and Biophysical Research Communications, Vol. 303, No. 4, 18.04.2003, p. 1193-1198.

Research output: Contribution to journalArticle

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