Characteristics and survival outcomes of hepatocellular carcinoma developed after hcv svr

Ming Lun Yeh, Po Cheng Liang, Pei Chien Tsai, Shu Chi Wang, Jennifer Leong, Eiichi Ogawa, Dae Won Jun, Cheng Hao Tseng, Charles Landis, Yasuhito Tanaka, Chung Feng Huang, Jun Hayashi, Yao Chun Hsu, Jee Fu Huang, Chia Yen Dai, Wan Long Chuang, Mindie H. Nguyen, Ming Lung Yu

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, p < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (p < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival.

Original languageEnglish
Article number3455
JournalCancers
Volume13
Issue number14
DOIs
StatePublished - 2021 Jul 2

Keywords

  • Chronic hepatitis C
  • Hepatitis C virus
  • Hepatocellular carcinoma
  • Survival
  • Viremia

Fingerprint

Dive into the research topics of 'Characteristics and survival outcomes of hepatocellular carcinoma developed after hcv svr'. Together they form a unique fingerprint.

Cite this