Cervical lymph node involvement above the supraclavicular fossa in breast cancer: Comparison with stage iiic (krog 18-02)

Jae Sik Kim, Kyubo Kim, Kyung Hwan Shin, Jin Ho Kim, Seung Do Ahn, Su Ssan Kim, Yong Bae Kim, Jee Suk Chang, Doo Ho Choi, Won Park, Tae Hyun Kim, Mison Chun, Jihye Cha, Jin Hee Kim, Dong Soo Lee, Sun Young Lee, Hae Jin Park

Research output: Contribution to journalArticle

Abstract

Purpose: We aimed to analyze the treatment outcomes of ipsilateral cervical lymph node (CLN)-positive breast cancer without other distant metastasis and compare the outcomes with those of supraclavicular lymph node (SCL)-positive breast cancer. Methods: Seventy-eight patients with breast cancer and ipsilateral CLN metastasis above the supraclavicular fossa (CLN[+] group) were treated at 7 institutions (2000–2014). Seventy-four patients received systemic chemotherapy and breast surgery followed by locoregional radiotherapy. Outcomes of the CLN(+) group were compared with those of the SCL(+) group, which included 183 patients with SCL involvement. Results: The median follow-up duration was 55.9 months. Twenty-two regional failures were found in 15 patients—axillary lymph node (LN) in 8, SCL in 6, internal mammary LN in 3, previously involved CLN in 4, and previously uninvolved ipsilateral CLN in one patient. The 5-year overall survival (OS), disease-free survival (DFS), locoregional relapse-free survival (LRRFS), and distant metastasis-free survival (DMFS) rates were 68.6%, 46.7%, 68.4%, and 57.0%, respectively. Neck dissection did not improve LRRFS and DFS (p = 0.86 and p = 0.26, respectively). Multivariate analysis showed that hormone receptor negativity and the presence of extracapsular extension were prognostic factors for poor DFS. On comparison with stage IIIC using propensity score matching, survival outcomes of the CLN(+) and SCL(+) groups were not different (5-year OS, p = 0.75; DFS, p = 0.88; LRRFS, p = 0.86; and DMFS, p = 0.45).Conclusion: The comparable clinical outcomes indicate that patients with breast cancer who have ipsilateral CLN metastasis without other distant metastasis may benefit from locoregional treatment of the ipsilateral breast and systemic therapies, as do those with N3c disease.

Original languageEnglish
Pages (from-to)194-204
Number of pages11
JournalJournal of Breast Cancer
Volume23
Issue number2
DOIs
StatePublished - 2020 Apr

Keywords

  • Breast
  • Carcinoma
  • Neoplasm metastasis
  • Neoplasm staging
  • Survival

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    Kim, J. S., Kim, K., Shin, K. H., Kim, J. H., Ahn, S. D., Kim, S. S., Kim, Y. B., Chang, J. S., Choi, D. H., Park, W., Kim, T. H., Chun, M., Cha, J., Kim, J. H., Lee, D. S., Lee, S. Y., & Park, H. J. (2020). Cervical lymph node involvement above the supraclavicular fossa in breast cancer: Comparison with stage iiic (krog 18-02). Journal of Breast Cancer, 23(2), 194-204. https://doi.org/10.4048/jbc.2020.23.e14