Catalase and PPARγ2 genotype and risk of systemic lupus erythematosus in Koreans

K. M. Eny, A. El-Sohemy, M. C. Cornelis, Yoon-Kyoung Sung, Sang Cheol Bae

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Catalase (CAT) and peroxisome proliferator activated receptor-γ2 (PPARγ2) are important regulators of oxidative stress and inflammation, which may contribute to the development of systemic lupus erythematosus (SLE). The objective of this study was to investigate the effects of genetic polymorphisms of CAT and PPARγ2 on risk and severity of SLE in a Korean population. DNA was isolated from blood samples collected from 345 patients with SLE and 400 controls. Genotyping for the - 262C → T polymorphism of CAT and the Pro12Ala polymorphism of PPARγ2 were performed by PCR-RFLP analysis. The severity of SLE was assessed using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI). No association was observed between genotypes for any of the clinical manifestations of SLE. CAT and PPARγ2 genotypes were not associated with either risk or severity of SLE. For subjects who were carriers of the high activity T allele for CAT and have the Pro/Pro genotype for PPARγ2, the odds ratio (95% confidence interval) for risk of SLE was 0.45 (0.23-1.08). Our results suggest that genetic polymorphisms of CAT and PPARy2 do not play a significant role in the development of SLE in a Korean population. A possible protective effect of a combined genotype warrants further investigation.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalLupus
Volume14
Issue number5
DOIs
StatePublished - 2005 Jun 13

Fingerprint

Peroxisome Proliferator-Activated Receptors
Systemic Lupus Erythematosus
Catalase
Genotype
Genetic Polymorphisms
Restriction Fragment Length Polymorphisms
Population
Oxidative Stress
Alleles
Odds Ratio
Confidence Intervals
Inflammation
Polymerase Chain Reaction
DNA

Keywords

  • Catalase
  • Genotype
  • Oxidative stress
  • PPARγ
  • Systemic lupus erythematosus

Cite this

Eny, K. M. ; El-Sohemy, A. ; Cornelis, M. C. ; Sung, Yoon-Kyoung ; Bae, Sang Cheol. / Catalase and PPARγ2 genotype and risk of systemic lupus erythematosus in Koreans. In: Lupus. 2005 ; Vol. 14, No. 5. pp. 351-355.
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Catalase and PPARγ2 genotype and risk of systemic lupus erythematosus in Koreans. / Eny, K. M.; El-Sohemy, A.; Cornelis, M. C.; Sung, Yoon-Kyoung; Bae, Sang Cheol.

In: Lupus, Vol. 14, No. 5, 13.06.2005, p. 351-355.

Research output: Contribution to journalArticle

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AU - Eny, K. M.

AU - El-Sohemy, A.

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