Carcinoembryonic antigen and patterns of recurrence after curative resection of the colorectal cancer

Young Park Ju, Kang Hong Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background/Aims: The influence of carcinoembryonic antigen (CEA) on patterns of recurrence after curative surgery in colorectal cancer was uncertain. We investigated the differences in the patterns of recurrence between the patients with elevated and normal preoperative serum CEA level. Methodology: A retrospective study was performed in 384 patients with primary colorectal adenocarcinoma of Dukes' classification A to C. Results: In Dukes' C2 rectal cancer, hepatic and local recurrence rates were higher in the patients with >10ng/mL of CEA than those were in the patients with ≤5ng/mL of CEA (p=0.028, p=0.049, respectively). Time to recurrence at lung was earlier in the patients with >10ng/mL of CEA than that was in the patients with ≤5ng/mL of CEA (p=0.0008). Conclusions: In Dukes' C2 rectal cancer patients with elevated preoperative serum CEA level, new options for adjuvant therapy should be evaluated as 1st line of therapy and special attention should be given to recurrence in liver during the early postoperative surveillance.

Original languageEnglish
Pages (from-to)1966-1969
Number of pages4
JournalHepato-Gastroenterology
Volume54
Issue number79
StatePublished - 2007 Oct 1

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Carcinoembryonic Antigen
Colorectal Neoplasms
Recurrence
Rectal Neoplasms
Liver
Serum
Adenocarcinoma
Retrospective Studies
Lung
Therapeutics

Keywords

  • Carcinoembryonic antigen
  • Colorectal cancer
  • Recurrence

Cite this

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abstract = "Background/Aims: The influence of carcinoembryonic antigen (CEA) on patterns of recurrence after curative surgery in colorectal cancer was uncertain. We investigated the differences in the patterns of recurrence between the patients with elevated and normal preoperative serum CEA level. Methodology: A retrospective study was performed in 384 patients with primary colorectal adenocarcinoma of Dukes' classification A to C. Results: In Dukes' C2 rectal cancer, hepatic and local recurrence rates were higher in the patients with >10ng/mL of CEA than those were in the patients with ≤5ng/mL of CEA (p=0.028, p=0.049, respectively). Time to recurrence at lung was earlier in the patients with >10ng/mL of CEA than that was in the patients with ≤5ng/mL of CEA (p=0.0008). Conclusions: In Dukes' C2 rectal cancer patients with elevated preoperative serum CEA level, new options for adjuvant therapy should be evaluated as 1st line of therapy and special attention should be given to recurrence in liver during the early postoperative surveillance.",
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Carcinoembryonic antigen and patterns of recurrence after curative resection of the colorectal cancer. / Ju, Young Park; Lee, Kang Hong.

In: Hepato-Gastroenterology, Vol. 54, No. 79, 01.10.2007, p. 1966-1969.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Carcinoembryonic antigen and patterns of recurrence after curative resection of the colorectal cancer

AU - Ju, Young Park

AU - Lee, Kang Hong

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Background/Aims: The influence of carcinoembryonic antigen (CEA) on patterns of recurrence after curative surgery in colorectal cancer was uncertain. We investigated the differences in the patterns of recurrence between the patients with elevated and normal preoperative serum CEA level. Methodology: A retrospective study was performed in 384 patients with primary colorectal adenocarcinoma of Dukes' classification A to C. Results: In Dukes' C2 rectal cancer, hepatic and local recurrence rates were higher in the patients with >10ng/mL of CEA than those were in the patients with ≤5ng/mL of CEA (p=0.028, p=0.049, respectively). Time to recurrence at lung was earlier in the patients with >10ng/mL of CEA than that was in the patients with ≤5ng/mL of CEA (p=0.0008). Conclusions: In Dukes' C2 rectal cancer patients with elevated preoperative serum CEA level, new options for adjuvant therapy should be evaluated as 1st line of therapy and special attention should be given to recurrence in liver during the early postoperative surveillance.

AB - Background/Aims: The influence of carcinoembryonic antigen (CEA) on patterns of recurrence after curative surgery in colorectal cancer was uncertain. We investigated the differences in the patterns of recurrence between the patients with elevated and normal preoperative serum CEA level. Methodology: A retrospective study was performed in 384 patients with primary colorectal adenocarcinoma of Dukes' classification A to C. Results: In Dukes' C2 rectal cancer, hepatic and local recurrence rates were higher in the patients with >10ng/mL of CEA than those were in the patients with ≤5ng/mL of CEA (p=0.028, p=0.049, respectively). Time to recurrence at lung was earlier in the patients with >10ng/mL of CEA than that was in the patients with ≤5ng/mL of CEA (p=0.0008). Conclusions: In Dukes' C2 rectal cancer patients with elevated preoperative serum CEA level, new options for adjuvant therapy should be evaluated as 1st line of therapy and special attention should be given to recurrence in liver during the early postoperative surveillance.

KW - Carcinoembryonic antigen

KW - Colorectal cancer

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