Carbon Dioxide-Generating PLG Nanoparticles for Controlled Anti-Cancer Drug Delivery

Hyeon Jin Jang, Eun Ju Jeong, Kuen Yong Lee

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

PURPOSE: Poly(D,L-lactide-co-glycolide) (PLG) nanoparticles containing doxorubicin and mineralized calcium carbonate were fabricated and their anti-tumor efficacy was tested using a neuroblastoma-bearing mouse model. METHODS: PLG nanoparticles were prepared by a double emulsion (water-in-oil-in-water; W/O/W) method. Calcium carbonate was mineralized within the PLG nanoparticles during the emulsion process. Rabies virus glycoprotein (RVG) peptide was chemically introduced to the surface of the PLG nanoparticles as a targeting moiety against neuroblastoma. The cytotoxicity and cellular uptake characteristics of these nanoparticles were investigated in vitro. Moreover, their therapeutic efficacy was evaluated using a tumor-bearing mouse model. RESULTS: Mineralized calcium carbonate in PLG nanoparticles was ionized at acidic pH and generated carbon dioxide gas, which resultantly accelerated the release of doxorubicin from the nanoparticles. RVG peptide-modified, gas-generating PLG nanoparticles showed a significantly enhanced targeting ability to neuroblastoma and an increased therapeutic efficacy in vivo as compared with free doxorubicin. CONCLUSIONS: Targeting ligand-modified polymer nanoparticles containing both anti-cancer drug and mineralized calcium carbonate could be useful for cancer treatment.

Original languageEnglish
Number of pages1
JournalPharmaceutical research
Volume35
Issue number3
DOIs
StatePublished - 2018 Feb 9

Keywords

  • cancer
  • drug delivery
  • gas-generation
  • polymer nanoparticle

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