Brief review of the role of glycogen synthase kinase-3β in amyotrophic lateral sclerosis

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenicmechanisms inmotor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy.

Original languageEnglish
Article number205761
JournalNeurology Research International
Volume2011
DOIs
StatePublished - 2011 Jan 1

Fingerprint

Glycogen Synthase Kinase 3
Amyotrophic Lateral Sclerosis
Cell Death
Apoptosis
Gene Expression

Cite this

@article{17af20c2570e4c63bbd926015b87c8c1,
title = "Brief review of the role of glycogen synthase kinase-3β in amyotrophic lateral sclerosis",
abstract = "Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenicmechanisms inmotor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy.",
author = "Seong-Ho Koh and Wonki Baek and Kim, {Seung Hyun}",
year = "2011",
month = "1",
day = "1",
doi = "10.1155/2011/205761",
language = "English",
volume = "2011",
journal = "Neurology Research International",
issn = "2090-1852",

}

Brief review of the role of glycogen synthase kinase-3β in amyotrophic lateral sclerosis. / Koh, Seong-Ho; Baek, Wonki; Kim, Seung Hyun.

In: Neurology Research International, Vol. 2011, 205761, 01.01.2011.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Brief review of the role of glycogen synthase kinase-3β in amyotrophic lateral sclerosis

AU - Koh, Seong-Ho

AU - Baek, Wonki

AU - Kim, Seung Hyun

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenicmechanisms inmotor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy.

AB - Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenicmechanisms inmotor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy.

UR - http://www.scopus.com/inward/record.url?scp=80051718959&partnerID=8YFLogxK

U2 - 10.1155/2011/205761

DO - 10.1155/2011/205761

M3 - Review article

AN - SCOPUS:80051718959

VL - 2011

JO - Neurology Research International

JF - Neurology Research International

SN - 2090-1852

M1 - 205761

ER -