Biological Conversion of Amino Acids to Higher Alcohols

Marwa M. El-Dalatony, Shouvik Saha, Sanjay Prabhu Govindwar, Reda A.I. Abou-Shanab, Byong-Hun Jeon

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

‘Higher’ alcohols, which contain more than two carbons, have a higher boiling point, higher cetane number, and higher energy density than ethanol. Blends of biodiesel and higher alcohols can be used in internal combustion engines as next-generation biofuels without any modification and are minimally corrosive over extensive use. Producing higher alcohols from biomass involves fermenting and metabolizing amino acids. In this review, we describe the pathways and regulatory mechanisms involved in amino acid bioprocessing to produce higher alcohols and the effects of amino acid supplementation as a nitrogen source for higher alcohol production. We also discuss the most recent approaches to improve higher alcohol production via genetic engineering technologies for three microorganisms: Saccharomyces cerevisiae, Clostridium spp., and Escherichia coli.

Original languageEnglish
JournalTrends in Biotechnology
DOIs
StatePublished - 2019 Jan 1

Fingerprint

Amino acids
Alcohols
Amino Acids
Biofuels
Genetic engineering
Caustics
Clostridium
Antiknock rating
Genetic Engineering
Boiling point
Engineering technology
Biodiesel
Internal combustion engines
Microorganisms
Yeast
Biomass
Escherichia coli
Saccharomyces cerevisiae
Ethanol
Nitrogen

Keywords

  • amino acids
  • bioprocessing
  • fermentation
  • genetic engineering
  • higher alcohols
  • microorganisms

Cite this

@article{e00e30e5e6704a3ebf832571e5fe0457,
title = "Biological Conversion of Amino Acids to Higher Alcohols",
abstract = "‘Higher’ alcohols, which contain more than two carbons, have a higher boiling point, higher cetane number, and higher energy density than ethanol. Blends of biodiesel and higher alcohols can be used in internal combustion engines as next-generation biofuels without any modification and are minimally corrosive over extensive use. Producing higher alcohols from biomass involves fermenting and metabolizing amino acids. In this review, we describe the pathways and regulatory mechanisms involved in amino acid bioprocessing to produce higher alcohols and the effects of amino acid supplementation as a nitrogen source for higher alcohol production. We also discuss the most recent approaches to improve higher alcohol production via genetic engineering technologies for three microorganisms: Saccharomyces cerevisiae, Clostridium spp., and Escherichia coli.",
keywords = "amino acids, bioprocessing, fermentation, genetic engineering, higher alcohols, microorganisms",
author = "El-Dalatony, {Marwa M.} and Shouvik Saha and Govindwar, {Sanjay Prabhu} and Abou-Shanab, {Reda A.I.} and Byong-Hun Jeon",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.tibtech.2019.01.011",
language = "English",
journal = "Trends in Biotechnology",
issn = "0167-7799",

}

Biological Conversion of Amino Acids to Higher Alcohols. / El-Dalatony, Marwa M.; Saha, Shouvik; Govindwar, Sanjay Prabhu; Abou-Shanab, Reda A.I.; Jeon, Byong-Hun.

In: Trends in Biotechnology, 01.01.2019.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Biological Conversion of Amino Acids to Higher Alcohols

AU - El-Dalatony, Marwa M.

AU - Saha, Shouvik

AU - Govindwar, Sanjay Prabhu

AU - Abou-Shanab, Reda A.I.

AU - Jeon, Byong-Hun

PY - 2019/1/1

Y1 - 2019/1/1

N2 - ‘Higher’ alcohols, which contain more than two carbons, have a higher boiling point, higher cetane number, and higher energy density than ethanol. Blends of biodiesel and higher alcohols can be used in internal combustion engines as next-generation biofuels without any modification and are minimally corrosive over extensive use. Producing higher alcohols from biomass involves fermenting and metabolizing amino acids. In this review, we describe the pathways and regulatory mechanisms involved in amino acid bioprocessing to produce higher alcohols and the effects of amino acid supplementation as a nitrogen source for higher alcohol production. We also discuss the most recent approaches to improve higher alcohol production via genetic engineering technologies for three microorganisms: Saccharomyces cerevisiae, Clostridium spp., and Escherichia coli.

AB - ‘Higher’ alcohols, which contain more than two carbons, have a higher boiling point, higher cetane number, and higher energy density than ethanol. Blends of biodiesel and higher alcohols can be used in internal combustion engines as next-generation biofuels without any modification and are minimally corrosive over extensive use. Producing higher alcohols from biomass involves fermenting and metabolizing amino acids. In this review, we describe the pathways and regulatory mechanisms involved in amino acid bioprocessing to produce higher alcohols and the effects of amino acid supplementation as a nitrogen source for higher alcohol production. We also discuss the most recent approaches to improve higher alcohol production via genetic engineering technologies for three microorganisms: Saccharomyces cerevisiae, Clostridium spp., and Escherichia coli.

KW - amino acids

KW - bioprocessing

KW - fermentation

KW - genetic engineering

KW - higher alcohols

KW - microorganisms

UR - http://www.scopus.com/inward/record.url?scp=85062626332&partnerID=8YFLogxK

U2 - 10.1016/j.tibtech.2019.01.011

DO - 10.1016/j.tibtech.2019.01.011

M3 - Review article

JO - Trends in Biotechnology

JF - Trends in Biotechnology

SN - 0167-7799

ER -