Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children

Eun Kyo Ha, Ju Hee Kim, Dong Keon Yon, Seung Won Lee, Mi Ae Kim, Kyung Suk Lee, Myongsoon Sung, Hye Mi Jee, Youn Ho Shin, Man Yong Han

Research output: Contribution to journalArticlepeer-review

Abstract

Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase reactant that mediates innate immune responses triggered by LPS. Recent studies indicated a positive correlation of circulating LBP level with chronic low-grade inflammation, a condition present in many non-communicable diseases. We determined the association of serum LBP concentration with allergic sensitization in a general pediatric population. Serum LBP was measured in a sample of children (n = 356; mean age = 9.6 ± 0.2 years) in this population-based cross-sectional study. Skin prick tests (SPTs) were performed to assess allergic sensitization to 22 common inhalant and food allergens. One hundred and seven children (30.1%) were nonsensitized, 160 (44.9%) were monosensitized, and 89 (25.0%) were polysensitized. Children who were mono- or polysensitized had a significantly higher median serum LBP level (25.5 ng/mL, inter-quartile range [IQR] 20.3–30.7) than those who were nonsensitized (20.3 ng/mL, IQR = 14.81–25.8, P < 0.0001). Multivariate logistic regression analysis with adjustment for confounders indicated that serum LBP level was positively associated with allergic sensitization overall (adjusted odds ratio [aOR] 1.041; 95% CI 1.007–1.076, P = 0.016), with sensitization to food allergens in particular (aOR 1.080, 95% CI 1.029–1.133, P = 0.002), but not with sensitization to aeroallergens (aOR 1.010, 95% CI 0.982–1.040, P = 0.467). LBP level was not associated with allergic diseases after adjustment. We suggest the possibility of sensitization to food allergens may be related to gut-derived low-grade inflammation, and large sized longitudinal investigations are needed to elucidate the relationship.

Original languageEnglish
Article number2143
JournalScientific reports
Volume11
Issue number1
DOIs
StatePublished - 2021 Dec

Fingerprint

Dive into the research topics of 'Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children'. Together they form a unique fingerprint.

Cite this