Association of complement alleles C4AQO and C4B5 with rheumatoid arthritis in Koreans

Myoung Hee Park, Myoung Don Oh, Yeong Wook Song, Hyun Joo Pai, Fujio Takeuchi, Katsushi Tokunaga, Gi Hyun Hong, Kyoung Sook Park

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3 Scopus citations

Abstract

Objective - To investigate the association of complement C4 allotypes with rheumatoid arthritis in Koreans. Methods - 65 rheumatoid arthritis patients and 255 controls were typed for C4 allotypes and HLA-A, B, C, DR, and DQ antigens. Results - The frequencies of C4AQO (32.3% v 14.9%, P < 0.005) and C4B5 (29.2% v 12.2%, P < 0.005) were significantly increased in rheumatoid arthritis patients compared with healthy control subjects. Among rheumatoid patients, the frequency of C4AQO was significantly increased in both the rheumatoid factor (RF) positive (27.3%) and the RF negative (66.7%) subgroups. The frequencies of C4B5 and HLA-DR4 were significantly increased only in RF positive subgroup. C4B5 was strongly associated with MLA-DR4, whereas C4AQO did not show association with DR4. Conclusions - In Koreans, C4AQO and C4B5 are associated with susceptibility to rheumatoid arthritis, as in the Japanese. C4B5 is strongly associated with HLA-DR4. C4AQO is considered to be a DR4 independent risk factor, and a disease susceptibility allele in linkage disequilibrium with C4AQO is suggested in Korean patients with rheumatoid arthritis.

Original languageEnglish
Pages (from-to)776-778
Number of pages3
JournalAnnals of the Rheumatic Diseases
Volume55
Issue number10
DOIs
StatePublished - 1996 Jan 1

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    Park, M. H., Oh, M. D., Song, Y. W., Pai, H. J., Takeuchi, F., Tokunaga, K., Hong, G. H., & Park, K. S. (1996). Association of complement alleles C4AQO and C4B5 with rheumatoid arthritis in Koreans. Annals of the Rheumatic Diseases, 55(10), 776-778. https://doi.org/10.1136/ard.55.10.776