Association of Asian mitochondrial DNA haplogroup B with new development of knee osteoarthritis in Koreans

Bon San Koo, Yoonah Song, Seunghun Lee, Yoon-Kyoung Sung, Kyoung Jin Shin, Nam H. Cho, Jae-Bum Jun

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aim: The aim of this study was to determine which mitochondrial DNA (mtDNA) haplogroup is associated with new development of knee osteoarthritis (OA). Methods: Epidemiologic data and knee radiographs with the Kellgren-Lawrence (K/L) score of the Ansung cohort study were prospectively obtained from the 2nd (2005-2006) and 6th follow-up periods (2013-2014). The mtDNA was analyzed by multiplex mutagenetically separated polymerase chain reaction to determine Asian mtDNA haplogroups (M, G, D, D4, D5, M7, M8, M9, M10, N, A, N9, R, F and B). The frequency of the mtDNA haplogroup was compared between participants with knee OA (K/L score ≥2 or total knee replacement arthroplasty [OA group]) and those without knee OA (K/L < 2 [control group]) at the 6th follow-up. Multiple logistic regression was used to determine the relative risk (RR) of mtDNA haplogroups for OA by adjusting for sex, age, body mass index, smoking and metabolic syndrome. Results: There were 1115 participants with epidemiological data, knee radiographs and DNA samples. Of these, 572 participants had a K/L score of 0 at the 2nd follow up, and 438 underwent knee radiography at the 6th follow up. Among the 438 participants, 160 were classified as having knee OA, and 278 were classified as the control group. The haplogroup B showed a significantly higher frequency in the OA group than in the control group (unadjusted RR = 1.794, P = 0.030; adjusted RR = 2.389, P = 0.004). Conclusion: Our data suggest that mtDNA haplogroup B contributed to the new development of knee OA in Koreans.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalInternational Journal of Rheumatic Diseases
Volume22
Issue number3
DOIs
StatePublished - 2019 Mar 1

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Knee Osteoarthritis
Mitochondrial DNA
Knee Replacement Arthroplasties
Osteoarthritis
Knee
Control Groups
Epidemiologic Methods
Radiography
Body Mass Index
Cohort Studies
Logistic Models
Smoking
Polymerase Chain Reaction
DNA

Keywords

  • Korea
  • mitochondrial DNA
  • osteoarthritis
  • osteoarthritis of knee
  • scoring methods

Cite this

@article{9e324d798c1340718886e9c20840e071,
title = "Association of Asian mitochondrial DNA haplogroup B with new development of knee osteoarthritis in Koreans",
abstract = "Aim: The aim of this study was to determine which mitochondrial DNA (mtDNA) haplogroup is associated with new development of knee osteoarthritis (OA). Methods: Epidemiologic data and knee radiographs with the Kellgren-Lawrence (K/L) score of the Ansung cohort study were prospectively obtained from the 2nd (2005-2006) and 6th follow-up periods (2013-2014). The mtDNA was analyzed by multiplex mutagenetically separated polymerase chain reaction to determine Asian mtDNA haplogroups (M, G, D, D4, D5, M7, M8, M9, M10, N, A, N9, R, F and B). The frequency of the mtDNA haplogroup was compared between participants with knee OA (K/L score ≥2 or total knee replacement arthroplasty [OA group]) and those without knee OA (K/L < 2 [control group]) at the 6th follow-up. Multiple logistic regression was used to determine the relative risk (RR) of mtDNA haplogroups for OA by adjusting for sex, age, body mass index, smoking and metabolic syndrome. Results: There were 1115 participants with epidemiological data, knee radiographs and DNA samples. Of these, 572 participants had a K/L score of 0 at the 2nd follow up, and 438 underwent knee radiography at the 6th follow up. Among the 438 participants, 160 were classified as having knee OA, and 278 were classified as the control group. The haplogroup B showed a significantly higher frequency in the OA group than in the control group (unadjusted RR = 1.794, P = 0.030; adjusted RR = 2.389, P = 0.004). Conclusion: Our data suggest that mtDNA haplogroup B contributed to the new development of knee OA in Koreans.",
keywords = "Korea, mitochondrial DNA, osteoarthritis, osteoarthritis of knee, scoring methods",
author = "Koo, {Bon San} and Yoonah Song and Seunghun Lee and Yoon-Kyoung Sung and Shin, {Kyoung Jin} and Cho, {Nam H.} and Jae-Bum Jun",
year = "2019",
month = "3",
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doi = "10.1111/1756-185X.13453",
language = "English",
volume = "22",
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journal = "International journal of rheumatic diseases",
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Association of Asian mitochondrial DNA haplogroup B with new development of knee osteoarthritis in Koreans. / Koo, Bon San; Song, Yoonah; Lee, Seunghun; Sung, Yoon-Kyoung; Shin, Kyoung Jin; Cho, Nam H.; Jun, Jae-Bum.

In: International Journal of Rheumatic Diseases, Vol. 22, No. 3, 01.03.2019, p. 411-416.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Association of Asian mitochondrial DNA haplogroup B with new development of knee osteoarthritis in Koreans

AU - Koo, Bon San

AU - Song, Yoonah

AU - Lee, Seunghun

AU - Sung, Yoon-Kyoung

AU - Shin, Kyoung Jin

AU - Cho, Nam H.

AU - Jun, Jae-Bum

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Aim: The aim of this study was to determine which mitochondrial DNA (mtDNA) haplogroup is associated with new development of knee osteoarthritis (OA). Methods: Epidemiologic data and knee radiographs with the Kellgren-Lawrence (K/L) score of the Ansung cohort study were prospectively obtained from the 2nd (2005-2006) and 6th follow-up periods (2013-2014). The mtDNA was analyzed by multiplex mutagenetically separated polymerase chain reaction to determine Asian mtDNA haplogroups (M, G, D, D4, D5, M7, M8, M9, M10, N, A, N9, R, F and B). The frequency of the mtDNA haplogroup was compared between participants with knee OA (K/L score ≥2 or total knee replacement arthroplasty [OA group]) and those without knee OA (K/L < 2 [control group]) at the 6th follow-up. Multiple logistic regression was used to determine the relative risk (RR) of mtDNA haplogroups for OA by adjusting for sex, age, body mass index, smoking and metabolic syndrome. Results: There were 1115 participants with epidemiological data, knee radiographs and DNA samples. Of these, 572 participants had a K/L score of 0 at the 2nd follow up, and 438 underwent knee radiography at the 6th follow up. Among the 438 participants, 160 were classified as having knee OA, and 278 were classified as the control group. The haplogroup B showed a significantly higher frequency in the OA group than in the control group (unadjusted RR = 1.794, P = 0.030; adjusted RR = 2.389, P = 0.004). Conclusion: Our data suggest that mtDNA haplogroup B contributed to the new development of knee OA in Koreans.

AB - Aim: The aim of this study was to determine which mitochondrial DNA (mtDNA) haplogroup is associated with new development of knee osteoarthritis (OA). Methods: Epidemiologic data and knee radiographs with the Kellgren-Lawrence (K/L) score of the Ansung cohort study were prospectively obtained from the 2nd (2005-2006) and 6th follow-up periods (2013-2014). The mtDNA was analyzed by multiplex mutagenetically separated polymerase chain reaction to determine Asian mtDNA haplogroups (M, G, D, D4, D5, M7, M8, M9, M10, N, A, N9, R, F and B). The frequency of the mtDNA haplogroup was compared between participants with knee OA (K/L score ≥2 or total knee replacement arthroplasty [OA group]) and those without knee OA (K/L < 2 [control group]) at the 6th follow-up. Multiple logistic regression was used to determine the relative risk (RR) of mtDNA haplogroups for OA by adjusting for sex, age, body mass index, smoking and metabolic syndrome. Results: There were 1115 participants with epidemiological data, knee radiographs and DNA samples. Of these, 572 participants had a K/L score of 0 at the 2nd follow up, and 438 underwent knee radiography at the 6th follow up. Among the 438 participants, 160 were classified as having knee OA, and 278 were classified as the control group. The haplogroup B showed a significantly higher frequency in the OA group than in the control group (unadjusted RR = 1.794, P = 0.030; adjusted RR = 2.389, P = 0.004). Conclusion: Our data suggest that mtDNA haplogroup B contributed to the new development of knee OA in Koreans.

KW - Korea

KW - mitochondrial DNA

KW - osteoarthritis

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KW - scoring methods

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