Association of adiponectin and leptin with serum lipids and erythrocyte omega-3 and omega-6 fatty acids in dialysis patients

W. S. An, Y. K. Son, S. E. Kim, K. H. Kim, H. R. Bae, S. Lee, Yongsoon Park, H. J. Kim, N. D. Vaziri

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aims: Besides regulating energy metabolism, leptin promotes and adiponectin suppresses inflammation which is a common feature of end-stage renal disease (ESRD). Omega-3 fatty acids (n-3FA) exert anti-inflammatory actions by inhibiting proinflammatory signal transduction pathways whereas arachidonic acid (an n-6FA) facilitates inflammation by mediating inflammatory signals and serving as precursor of proinflammatory eicosanoids. Given the functional overlap between adipokines and n-3FA and n-6FA, we sought to explore their interrelationship in patients with ESRD. Methods: 44 ESRD patientsmaintained on hemodialysis (HD), 29 patients receiving peritoneal dialysis (PD), and 10 healthy subjects were enrolled. Body mass index (BMI), plasma leptin, adiponectin, lipids and CRP and erythrocyte fatty acids were measured. Results: Compared to controls adiponectin was elevated and leptin level was reduced in the ESRD group. Adiponectin levels were comparable among PD and HD patients, but leptin and BMI were higher in PD than in HD patients. Despite comparable BMIs, female patients had higher leptin than male patients. Leptin levels were positively associations with BMI, total and LDL cholesterol whereas adiponectin was inversely related with BMI, triglycerides and CRP and directly associated with HDL cholesterol in ESRD patients. Plasma adiponectin was directly associated with erythrocyte n-3 FA(r = 0.581, p = 0.023) and inversely associated with n-6FA (r = -0.640, p = 0.010) in the HD patients. Conclusion: A direct association was found between plasma levels of adiponectin and HDL and erythrocyte n-3FA in ESRD patients. Prospective trials are needed to explore the effect of n-3FA supplementation on plasma adipokines and markers of oxidative stress and inflammation in this population.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalClinical Nephrology
Volume75
Issue number3
DOIs
StatePublished - 2011 Mar 1

Fingerprint

Omega-6 Fatty Acids
Adiponectin
Leptin
Dialysis
Erythrocytes
Lipids
Chronic Kidney Failure
Serum
Renal Dialysis
Body Mass Index
Peritoneal Dialysis
Adipokines
Inflammation
Eicosanoids
Omega-3 Fatty Acids
Arachidonic Acid
LDL Cholesterol
HDL Cholesterol
Energy Metabolism
Signal Transduction

Keywords

  • Adiponectin
  • Dialysis
  • ESRD
  • Leptin
  • Omega-3 fatty acids

Cite this

An, W. S. ; Son, Y. K. ; Kim, S. E. ; Kim, K. H. ; Bae, H. R. ; Lee, S. ; Park, Yongsoon ; Kim, H. J. ; Vaziri, N. D. / Association of adiponectin and leptin with serum lipids and erythrocyte omega-3 and omega-6 fatty acids in dialysis patients. In: Clinical Nephrology. 2011 ; Vol. 75, No. 3. pp. 195-203.
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Association of adiponectin and leptin with serum lipids and erythrocyte omega-3 and omega-6 fatty acids in dialysis patients. / An, W. S.; Son, Y. K.; Kim, S. E.; Kim, K. H.; Bae, H. R.; Lee, S.; Park, Yongsoon; Kim, H. J.; Vaziri, N. D.

In: Clinical Nephrology, Vol. 75, No. 3, 01.03.2011, p. 195-203.

Research output: Contribution to journalArticle

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T1 - Association of adiponectin and leptin with serum lipids and erythrocyte omega-3 and omega-6 fatty acids in dialysis patients

AU - An, W. S.

AU - Son, Y. K.

AU - Kim, S. E.

AU - Kim, K. H.

AU - Bae, H. R.

AU - Lee, S.

AU - Park, Yongsoon

AU - Kim, H. J.

AU - Vaziri, N. D.

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AB - Aims: Besides regulating energy metabolism, leptin promotes and adiponectin suppresses inflammation which is a common feature of end-stage renal disease (ESRD). Omega-3 fatty acids (n-3FA) exert anti-inflammatory actions by inhibiting proinflammatory signal transduction pathways whereas arachidonic acid (an n-6FA) facilitates inflammation by mediating inflammatory signals and serving as precursor of proinflammatory eicosanoids. Given the functional overlap between adipokines and n-3FA and n-6FA, we sought to explore their interrelationship in patients with ESRD. Methods: 44 ESRD patientsmaintained on hemodialysis (HD), 29 patients receiving peritoneal dialysis (PD), and 10 healthy subjects were enrolled. Body mass index (BMI), plasma leptin, adiponectin, lipids and CRP and erythrocyte fatty acids were measured. Results: Compared to controls adiponectin was elevated and leptin level was reduced in the ESRD group. Adiponectin levels were comparable among PD and HD patients, but leptin and BMI were higher in PD than in HD patients. Despite comparable BMIs, female patients had higher leptin than male patients. Leptin levels were positively associations with BMI, total and LDL cholesterol whereas adiponectin was inversely related with BMI, triglycerides and CRP and directly associated with HDL cholesterol in ESRD patients. Plasma adiponectin was directly associated with erythrocyte n-3 FA(r = 0.581, p = 0.023) and inversely associated with n-6FA (r = -0.640, p = 0.010) in the HD patients. Conclusion: A direct association was found between plasma levels of adiponectin and HDL and erythrocyte n-3FA in ESRD patients. Prospective trials are needed to explore the effect of n-3FA supplementation on plasma adipokines and markers of oxidative stress and inflammation in this population.

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