Association between the dietary inflammatory index and risk for cancer recurrence and mortality among patients with breast cancer

Hyeonjeong Jang, Min Sung Chung, Shin Sook Kang, Yongsoon Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The dietary inflammatory index (DII) has been associated with breast cancer incidence and survival. However, the association between DII and cancer recurrence and mortality among patients with breast cancer has not been investigated. Therefore, the present study aimed to investigate whether DII was positively associated with risk for cancer recurrence and overall mortality among patients with breast cancer. Among 511 women (51.9 ± 10.7 years; stage 0–3) who underwent breast cancer surgery, 88 had cancer recurrence, and 44 died during follow–up until 213 months (average disease free survival of 84.3 ± 42.4 months and overall survival of 69.3 ± 38.9 months). The DII assessed after surgery (5.4 ± 5.2 months after diagnosis) was significantly higher in patients with recurrence than those without recurrence, and Cox proportional hazards regression analysis showed that it was positively associated with the risk for cancer recurrence (hazard ratio (HR) 2.347, confidence interval (CI) 1.17–4.71) and overall mortality (HR 3.049, CI 1.08–8.83) after adjusting for confounding factors. Disease-free survival and overall survival rates were significantly lower in patients with higher DII scores. In addition, the DII was positively associated with the risk for cancer recurrence according to prognostic factors, such as age (<50 years), premenopausal status, body mass index (≥25 kg/m 2 ), HR+, tumor size (>2 cm), and presence of lymph node metastasis. The present study showed that anti-inflammatory diets may decrease the risk of cancer recurrence and overall mortality in patients with breast cancer, particularly those with prognostic factors, such as younger age, premenopausal status, obesity, HR+ breast cancer, tumor size >2 cm, and presence of lymph node metastasis.

Original languageEnglish
Article number1095
JournalNutrients
Volume10
Issue number8
DOIs
StatePublished - 2018 Aug 15

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breast neoplasms
Breast Neoplasms
Recurrence
neoplasms
Mortality
Neoplasms
metastasis
Disease-Free Survival
lymph nodes
confidence interval
surgery
Lymph Nodes
Confidence Intervals
Neoplasm Metastasis
Survival
body mass index
Body Mass Index
obesity
Anti-Inflammatory Agents
regression analysis

Keywords

  • Breast cancer
  • Diet
  • Inflammation
  • Mortality

Cite this

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title = "Association between the dietary inflammatory index and risk for cancer recurrence and mortality among patients with breast cancer",
abstract = "The dietary inflammatory index (DII) has been associated with breast cancer incidence and survival. However, the association between DII and cancer recurrence and mortality among patients with breast cancer has not been investigated. Therefore, the present study aimed to investigate whether DII was positively associated with risk for cancer recurrence and overall mortality among patients with breast cancer. Among 511 women (51.9 ± 10.7 years; stage 0–3) who underwent breast cancer surgery, 88 had cancer recurrence, and 44 died during follow–up until 213 months (average disease free survival of 84.3 ± 42.4 months and overall survival of 69.3 ± 38.9 months). The DII assessed after surgery (5.4 ± 5.2 months after diagnosis) was significantly higher in patients with recurrence than those without recurrence, and Cox proportional hazards regression analysis showed that it was positively associated with the risk for cancer recurrence (hazard ratio (HR) 2.347, confidence interval (CI) 1.17–4.71) and overall mortality (HR 3.049, CI 1.08–8.83) after adjusting for confounding factors. Disease-free survival and overall survival rates were significantly lower in patients with higher DII scores. In addition, the DII was positively associated with the risk for cancer recurrence according to prognostic factors, such as age (<50 years), premenopausal status, body mass index (≥25 kg/m 2 ), HR+, tumor size (>2 cm), and presence of lymph node metastasis. The present study showed that anti-inflammatory diets may decrease the risk of cancer recurrence and overall mortality in patients with breast cancer, particularly those with prognostic factors, such as younger age, premenopausal status, obesity, HR+ breast cancer, tumor size >2 cm, and presence of lymph node metastasis.",
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Association between the dietary inflammatory index and risk for cancer recurrence and mortality among patients with breast cancer. / Jang, Hyeonjeong; Chung, Min Sung; Kang, Shin Sook; Park, Yongsoon.

In: Nutrients, Vol. 10, No. 8, 1095, 15.08.2018.

Research output: Contribution to journalArticle

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AU - Chung, Min Sung

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AU - Park, Yongsoon

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