Antihypertensive drugs and the risk of cancer: A nationwide cohort study

In Jeong Cho, Jeong Hun Shin, Mi Hyang Jung, Chae Young Kang, Jinseub Hwang, Chang Hee Kwon, Woohyeun Kim, Dae Hee Kim, Chan Joo Lee, Si Hyuck Kang, Ju Hee Lee, Hack Lyoung Kim, Hyue Mee Kim, Iksung Cho, Hae Young Lee, Wook Jin Chung, Sang Hyun Ihm, Kwang Il Kim, Eun Joo Cho, Il Suk SohnSungha Park, Jinho Shin, Sung Kee Ryu, Jang Young Kim, Seok Min Kang, Myeong Chan Cho, Wook Bum Pyun, Ki Chul Sung

Research output: Contribution to journalArticlepeer-review

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Abstract

We sought to assess the association between common antihypertensive drugs and the risk of incident cancer in treated hypertensive patients. Using the Korean National Health Insurance Service database, the risk of cancer incidence was analyzed in patients with hypertension who were initially free of cancer and used the following antihypertensive drug classes: Angiotensin-convert-ing enzyme inhibitors (ACEIs); angiotensin receptor blockers (ARBs); beta blockers (BBs); calcium channel blockers (CCBs); and diuretics. During a median follow-up of 8.6 years, there were 4513 (6.4%) overall cancer incidences from an initial 70,549 individuals taking antihypertensive drugs. ARB use was associated with a decreased risk for overall cancer in a crude model (hazard ratio (HR): 0.744, 95% confidence interval (CI): 0.696–0.794) and a fully adjusted model (HR: 0.833, 95% CI: 0.775–0.896) compared with individuals not taking ARBs. Other antihypertensive drugs, including ACEIs, CCBs, BBs, and diuretics, did not show significant associations with incident cancer overall. The long-term use of ARBs was significantly associated with a reduced risk of incident cancer over time. The users of common antihypertensive medications were not associated with an increased risk of cancer overall compared to users of other classes of antihypertensive drugs. ARB use was inde-pendently associated with a decreased risk of cancer overall compared to other antihypertensive drugs.

Original languageEnglish
Article number771
Pages (from-to)1-13
Number of pages13
JournalJournal of Clinical Medicine
Volume10
Issue number4
DOIs
StatePublished - 2021 Feb 2

Keywords

  • Antihypertensive agent
  • Cohort study
  • Neoplasms

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