Anoctamin 1 in secretory epithelia

Yongwoo Jang, Uhtaek Oh

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Fluid and electrolyte releasing from secretory epithelia are elaborately regulated by orchestrated activity of ion channels. The activity of chloride channel at the apical membrane decides on the direction and the rate of secretory fluid and electrolyte. Chloride-dependent secretion is conventionally associated with intracellular increases in two second messengers, cAMP and Ca2+, responding to luminal purinergic and basolateral adrenergic or cholinergic stimulation. While it is broadly regarded that cAMP-dependent Cl- secretion is regulated by cystic fibrosis transmembrane conductance regulator (CFTR), Ca2+-activated Cl- channel (CaCC) had been veiled for quite some time. Now, Anoctamin 1 (ANO1 or TMEM16A) confers Ca2+-activated Cl- currents. Ano 1 and its paralogs have been actively investigated for multiple functions underlying Ca2+-activated Cl- efflux and fluid secretion in a variety of secretory epithelial cells. In this review, we will discuss recent advances in the secretory function and signaling of ANO1 in the secretory epithelia, such as airways, intestines, and salivary glands.

Original languageEnglish
Pages (from-to)355-361
Number of pages7
JournalCell Calcium
Volume55
Issue number6
DOIs
StatePublished - 2014 Jun
Externally publishedYes

Keywords

  • Airway epithelium
  • Anoctamin1
  • Fluid secretion
  • Intestinal epithelium
  • Salivary gland acinar cell
  • TMEM16A

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