With the development of imaging technologies, supraclavicular (SCN) and/or internal mammary nodes are increasingly detected in locally advanced breast cancers. The impact of aggressive treatment such as SCN excision was investigated via a large-scale multicenter study. When breast surgery, systemic therapy, and adjuvant radiotherapy were given, SCN excision did not improve locoregional control or survival.
- Internal mammary node
- Non-axillary regional lymph node
- Prognostic factors
- Radiation therapy
- Upfront surgery