Advances in surface plasmon resonance–based biosensor technologies for cancer biomarker detection

Abdelmonaim Azzouz, Lamia Hejji, Ki Hyun Kim, Deepak Kukkar, Badredine Souhail, Neha Bhardwaj, Richard J.C. Brown, Wei Zhang

Research output: Contribution to journalReview articlepeer-review


Surface plasmon resonance approach is a highly useful option to offer optical and label-free detection of target bioanalytes with numerous advantages (e.g., low-cost fabrication, appreciable sensitivity, label-free detection, and outstanding accuracy). As such, it allows early diagnosis of cancer biomarkers to monitor tumor progression and to prevent the recurrence of oncogenic tumors. This work highlights the recent progress in SPR biosensing technology for the diagnosis of various cancer types (e.g., lung, breast, prostate, and ovarian). Further, the performance of various SPR biosensors is also evaluated in terms of the basic quality assurance criteria (e.g., limit of detection (LOD), selectivity, sensor response time, and reusability). Finally, the limitations and future challenges associated with SPR biosensors are also discussed with respect to cancer biomarker detection.

Original languageEnglish
Article number113767
JournalBiosensors and Bioelectronics
StatePublished - 2022 Feb 1


  • Biosensing
  • Cancer
  • Nanomaterials
  • Surface plasmon resonance


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