Abdominal Wall Thickness Affects Liver Stiffness Measurements by 2-D Shear Wave Elastography in Patients with Chronic Liver Disease

Young Seo Cho, Sanghyeok Lim, Yong Soo Kim, Tae Yeob Kim, Woo Kyoung Jeong, Joo Hyun Sohn

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This study was conducted to define the effect of abdominal wall thickness (AWT) and its composition on the level of confidence in liver stiffness (LS) measurements obtained with 2-D shear wave elastography (2-D-SWE) in patients with chronic liver disease. In this retrospective study, a total of 1291 patients who underwent LS measurement by 2-D-SWE were enrolled. The abdominal wall was divided into three layers: layer 1 extended from the skin to the subcutaneous fat layer; layer 2 was the muscle layer; and layer 3 extended from the peritoneum to the liver capsule (including the omental fat layer, if present). We regarded the sums of layers 1–3 and layers 1 and 3 as the AWT and non-muscular layer thickness (NMT). Age/sex/body mass index-adjusted multivariate logistic regression analysis was performed to identify factors influencing the level of confidence of LS measurements. Three hundred eighty-six patients (29.9%) were classified in the unreliable LS group (standard deviation/median LS > 0.1). The fourth quartile of AWT and third and fourth quartiles of NMT/AWT were significantly associated with unreliable LS values (odds ratios = 2.103, 1.753 and 1.695, respectively). In conclusion, high AWT and NMT/AWT ratios reduce the confidence in LS measurements obtained with 2-D-SWE.

Original languageEnglish
Pages (from-to)2697-2703
Number of pages7
JournalUltrasound in Medicine and Biology
Volume45
Issue number10
DOIs
StatePublished - 2019 Oct 1

Fingerprint

Elasticity Imaging Techniques
Abdominal Wall
liver
S waves
Liver Diseases
stiffness
Chronic Disease
Liver
quartiles
confidence
fats
Subcutaneous Fat
Peritoneum
peritoneum
Capsules
Body Mass Index
thickness ratio
Retrospective Studies
Logistic Models
Fats

Keywords

  • Abdominal wall
  • Elasticity imaging techniques
  • Fibrosis
  • Liver

Cite this

Cho, Young Seo ; Lim, Sanghyeok ; Kim, Yong Soo ; Kim, Tae Yeob ; Jeong, Woo Kyoung ; Sohn, Joo Hyun. / Abdominal Wall Thickness Affects Liver Stiffness Measurements by 2-D Shear Wave Elastography in Patients with Chronic Liver Disease. In: Ultrasound in Medicine and Biology. 2019 ; Vol. 45, No. 10. pp. 2697-2703.
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abstract = "This study was conducted to define the effect of abdominal wall thickness (AWT) and its composition on the level of confidence in liver stiffness (LS) measurements obtained with 2-D shear wave elastography (2-D-SWE) in patients with chronic liver disease. In this retrospective study, a total of 1291 patients who underwent LS measurement by 2-D-SWE were enrolled. The abdominal wall was divided into three layers: layer 1 extended from the skin to the subcutaneous fat layer; layer 2 was the muscle layer; and layer 3 extended from the peritoneum to the liver capsule (including the omental fat layer, if present). We regarded the sums of layers 1–3 and layers 1 and 3 as the AWT and non-muscular layer thickness (NMT). Age/sex/body mass index-adjusted multivariate logistic regression analysis was performed to identify factors influencing the level of confidence of LS measurements. Three hundred eighty-six patients (29.9{\%}) were classified in the unreliable LS group (standard deviation/median LS > 0.1). The fourth quartile of AWT and third and fourth quartiles of NMT/AWT were significantly associated with unreliable LS values (odds ratios = 2.103, 1.753 and 1.695, respectively). In conclusion, high AWT and NMT/AWT ratios reduce the confidence in LS measurements obtained with 2-D-SWE.",
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Abdominal Wall Thickness Affects Liver Stiffness Measurements by 2-D Shear Wave Elastography in Patients with Chronic Liver Disease. / Cho, Young Seo; Lim, Sanghyeok; Kim, Yong Soo; Kim, Tae Yeob; Jeong, Woo Kyoung; Sohn, Joo Hyun.

In: Ultrasound in Medicine and Biology, Vol. 45, No. 10, 01.10.2019, p. 2697-2703.

Research output: Contribution to journalArticleResearchpeer-review

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