A label-free single breast cancer cell detection using h-BN sandwiched MoS2 field-effect transistor combined with PDMS-constriction-channel

Jusin Lee, Yousang Yoon, Heewon Yang, Yoojeong An, Onejae Sul, Su Jae Lee, Seung Beck Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The electrical properties of MoS2 make it highly sensitive to the surface charge density of a cell on MoS2 channel. Here, we fabricated a h-BN sandwiched MoS2 FET integrated with a microfluidic PDMS-constriction-channel for the effective positioning and sensing of cancer cells. By combining advantages of sensitive electrical properties of 2D material and microfluidic geometry, our constriction-channel combined MoS2 sensor could distinguish a single breast cancer cell from the electrolyte by the positive threshold voltage shift of the sensor.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages503-504
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - 2020 Jan 1
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 2017 Oct 222017 Oct 26

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period17/10/2217/10/26

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Keywords

  • Cancer cell
  • Detection
  • Field-effect transistor
  • H-BN
  • Label-free
  • MDA-MB-231
  • MoS2
  • Single cell

Cite this

Lee, J., Yoon, Y., Yang, H., An, Y., Sul, O., Lee, S. J., & Lee, S. B. (2020). A label-free single breast cancer cell detection using h-BN sandwiched MoS2 field-effect transistor combined with PDMS-constriction-channel. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 503-504). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.