A case of pretibial myxedema associated with hypothyroidism and thyroid-stimulating hormone receptor antibodies

Sang Oh, Han Cho, Yoon Jung, Min Kyung Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Pretibial myxedema (PTM) is an infiltrative dermopathy seen in Graves' disease. It is also infrequently associated with hypothyroidism. Here, we describe a rare case of PTM with hypothyroidism in which thyroid-stimulating hormone receptor antibodies were found. An 82-year-old female presented with a 1-year history of a large pruritic plaque which was present over both her legs and feet. Histopathology of a skin biopsy showed markedly increased dermal mucin. These changes were suggestive of PTM. This case provides evidence that an autoimmune mechanism could play a central pathogenetic role in such cutaneous manifestations.

Original languageEnglish
Pages (from-to)166-169
Number of pages4
JournalDermatologica Sinica
Volume37
Issue number3
DOIs
StatePublished - 2019 Jul 1
Externally publishedYes

Keywords

  • Hypothyroidism
  • pretibial myxedema
  • thyroid-stimulating hormone receptor antibodies

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