3D Printed Bioresponsive Devices with Selective Permeability Inspired by Eggshell Membrane for Effective Biochemical Conversion

Yale Jeon, Min Soo Jeon, Jongoh Shin, Sangrak Jin, Jonghun Yi, Seulgi Kang, Sun Chang Kim, Byung Kwan Cho, Jung Kul Lee, Dong Rip Kim

Research output: Contribution to journalArticle

Abstract

Eggshell membrane has selective permeability that enables gas or liquid molecules to pass through while effectively preventing migration of microbial species. Herein, inspired by the architecture of the eggshell membrane, we employ three-dimensional (3D) printing techniques to realize bioresponsive devices with excellent selective permeability for effective biochemical conversion. The fabricated devices show 3D conductive carbon nanofiber membranes in which precultured microbial cells are controllably deployed. The resulting outcome provides excellent selective permeability between chemical and biological species, which enables acquisition of target responses generated by biological species confined within the device upon input signals. In addition, electrically conductive carbon nanofiber networks provide a platform for real-time monitoring of metabolism of microbial cells in the device. The suggested platform represents an effort to broaden microbial applications by constructing biologically programmed devices for desired responses enabled by designated deployment of engineered cells in a securely confined manner within enclosed membranes using 3D printing methods.

Original languageEnglish
Pages (from-to)30112-30119
Number of pages8
JournalACS Applied Materials and Interfaces
Volume12
Issue number27
DOIs
StatePublished - 2020 Jul 8

Keywords

  • 3D printing
  • biochemical conversion
  • carbon nanofiber
  • membrane
  • microbial cell
  • selective permeability

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