• 4263 Citations
  • 33 h-Index
1990 …2020

Research output per year

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Research Output

  • 4263 Citations
  • 33 h-Index
  • 110 Article
  • 7 Review article
  • 1 Comment/debate
2020

Crystal structure of the mouse endonuclease G

Park, K. H., Yoon, S. M., Song, H. N., Yang, J. H., Ryu, S. E. & Woo, E. J., 2020 May 21, In : Biochemical and Biophysical Research Communications. 526, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

MGOS: A library for molecular geometry and its operating system

Kim, D. S., Ryu, J., Cho, Y., Lee, M., Cha, J., Song, C., Kim, S. W., Laskowski, R. A., Sugihara, K., Bhak, J. & Ryu, S. E., 2020 Jun, In : Computer Physics Communications. 251, 107101.

Research output: Contribution to journalArticle

Open Access
2019

Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition

Yeon Kim, B., Hee Yoon, J., Kim, M., Nyoung Kim, J., Park, H., Eon Ryu, S. & Lee, S., 2019 Jul 15, In : Bioorganic and Medicinal Chemistry Letters. 29, 14, p. 1746-1748 3 p.

Research output: Contribution to journalArticle

Virtual Screening and Biochemical Evaluation to Identify the Allosteric Inhibitors of Dual Specificity Phosphatase 1

Park, H., Kim, M., Park, T. H., Jeon, T. J., Chun, H. J. & Eon Ryu, S., 2019 Mar, In : Bulletin of the Korean Chemical Society. 40, 3, p. 236-242 7 p.

Research output: Contribution to journalArticle

2018

BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus

Shin, W., Lee, H. T., Lim, H., Lee, S. H., Son, J. Y., Lee, J. U., Yoo, K. Y., Ryu, S. E., Rhie, J., Lee, J. Y. & Heo, Y. S., 2018 Dec 1, In : Nature Communications. 9, 1, 1200.

Research output: Contribution to journalArticle

7 Scopus citations

Two intermediate states of the conformational switch in dual specificity phosphatase 13a

Wei, C. H., Min, H. G., Kim, M., Kim, G. H., Chun, H. J. & Ryu, S. E., 2018 Feb, In : Pharmacological Research. 128, p. 211-219 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab

Lee, H. T., Lee, J. Y., Lim, H., Lee, S. H., Moon, Y. J., Pyo, H. J., Ryu, S. E., Shin, W. & Heo, Y. S., 2017 Dec 1, In : Scientific reports. 7, 1, 5532.

Research output: Contribution to journalArticle

52 Scopus citations

Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28

Ku, B., Hong, W., Keum, C. W., Kim, M., Ryu, H., Jeon, D., Shin, H. C., Kim, J. H., Kim, S. J. & Ryu, S. E., 2017 Nov, In : PLoS ONE. 12, 11, e0187701.

Research output: Contribution to journalArticle

2 Scopus citations
2016

BetaSCPWeb: side-chain prediction for protein structures using Voronoi diagrams and geometry prioritization

Ryu, J., Lee, M., Cha, J., Laskowski, R. A., Ryu, S. E. & Kim, D. S., 2016 Jul 8, In : Nucleic Acids Research. 44, W1, p. W416-W423

Research output: Contribution to journalArticle

17 Scopus citations

Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension

Lee, H. S., Ku, B., Park, T. H., Park, H., Choi, J. K., Chang, K. T., Kim, C. H., Ryu, S. E. & Kim, S. J., 2016 Jan 1, In : Bioorganic and Medicinal Chemistry Letters. 26, 1, p. 87-93 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy

Lee, J. Y., Lee, H. T., Shin, W., Chae, J., Choi, J., Kim, S. H., Lim, H., Won Heo, T., Park, K. Y., Lee, Y. J., Ryu, S. E., Son, J. Y., Lee, J. U. & Heo, Y. S., 2016 Oct 31, In : Nature Communications. 7, 13354.

Research output: Contribution to journalArticle

101 Scopus citations
2015

BetaCavityWeb: A webserver for molecular voids and channels

Kim, J. K., Cho, Y., Lee, M., Laskowski, R. A., Ryu, S. E., Sugihara, K. & Kim, D. S., 2015 Jan 1, In : Nucleic Acids Research. 43, W1, p. W413-W418

Research output: Contribution to journalArticle

19 Scopus citations

Enhanced humanization and affinity maturation of neutralizing anti-hepatitis B virus preS1 antibody based on antigen-antibody complex structure

Kim, J. H., Gripon, P., Bouezzedine, F., Jeong, M. S., Chi, S. W., Ryu, S. E. & Hong, H. J., 2015 Jan 16, In : FEBS Letters. 589, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Structure of the catalytic phosphatase domain of MTMR8: Implications for dimerization, membrane association and reversible oxidation

Yoo, K. Y., Son, J. Y., Lee, J. U., Shin, W., Im, D. W., Kim, S. J., Ryu, S. E. & Heo, Y. S., 2015 Jul 1, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 1528-1539 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

BetaVoid: Molecular voids via beta-complexes and Voronoi diagrams

Kim, J. K., Cho, Y., Laskowski, R. A., Ryu, S. E., Sugihara, K. & Kim, D. S., 2014 Sep, In : Proteins: Structure, Function and Bioinformatics. 82, 9, p. 1829-1849 21 p.

Research output: Contribution to journalArticle

11 Scopus citations

Crystallization and preliminary X-ray crystallographic analysis of the PH-GRAM domain of human MTMR4

Lee, J. U., Son, J. Y., Yoo, K. Y., Shin, W., Im, D. W., Kim, S. J., Ryu, S. E. & Heo, Y. S., 2014 Aug 29, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 70, 9, p. 1280-1283 4 p.

Research output: Contribution to journalArticle

Discovery of novel DUSP16 phosphatase inhibitors through virtual screening with homology modeled protein structure

Park, H., Park, S. Y., Nam, S. W. & Ryu, S. E., 2014 Dec 27, In : Journal of Biomolecular Screening. 19, 10, p. 1383-1390 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Discovery of novel DUSP4 inhibitors through the virtual screening with docking simulations

Park, H., Jeon, T. J., Chien, P. N., Park, S. Y., Oh, S. M., Kim, S. J. & Ryu, S. E., 2014 Sep 20, In : Bulletin of the Korean Chemical Society. 35, 9, p. 2655-2659 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Expression, purification, crystallization and preliminary crystallographic analysis of human myotubularin-related protein 3

Son, J. Y., Lee, J. U., Yoo, K. Y., Shin, W., Im, D. W., Kim, S. J., Ryu, S. E. & Heo, Y. S., 2014 Sep 1, In : Acta Crystallographica Section:F Structural Biology Communications. 70, p. 1240-1243 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

The family-wide structure and function of human dual-specificity protein phosphatases

Jeong, D. G., Wei, C. H., Ku, B., Jeon, T. J., Chien, P. N., Kim, J. K., Park, S. Y., Hwang, H. S., Ryu, S. Y., Park, H., Kim, D. S., Kim, S. J. & Ryu, S. E., 2014 Feb 1, In : Acta Crystallographica Section D: Biological Crystallography. 70, 2, p. 421-435 15 p.

Research output: Contribution to journalArticle

25 Scopus citations
2013

201Tl heart-liver radioactivity uptake ratio and prediction of decompensation in patients with cirrhosis

Lee, M. H., Tae, H. J., Jun, D. W., Ryu, S. E., Choi, Y. Y., Kwak, M. J. & Kang, J. S., 2013 Mar 1, In : Clinical Nuclear Medicine. 38, 3, p. 169-174 6 p.

Research output: Contribution to journalArticle

Dual-mode enhancement of metallothionein protein with cell transduction and retention peptide fusion

Lim, K. S., Lim, M. H., Won, Y. W., Kim, J. K., Kang, Y. C., Park, E. J., Chae, J. W., Kim, S. M., Ryu, S. E., Pak, Y. K. & Kim, Y. H., 2013 Jan 1, In : Journal of Controlled Release. 171, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Homology modeling and virtual screening approaches to identify potent inhibitors of slingshot phosphatase 1

Park, H., Park, S. Y. & Ryu, S. E., 2013 Feb 1, In : Journal of Molecular Graphics and Modelling. 39, p. 65-70 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of potent leukocyte common antigen-related phosphatase inhibitors via structure-based virtual screening

Park, H., Chien, P. N., Chun, H. J. & Ryu, S. E., 2013 Jul 20, In : Bulletin of the Korean Chemical Society. 34, 7, p. 2006-2010 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Identification of potent VHZ phosphatase inhibitors with structure-based virtual screening

Park, H., Park, S. Y., Oh, J. J. & Ryu, S. E., 2013 Feb, In : Journal of Biomolecular Screening. 18, 2, p. 226-231 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Protein tyrosine phosphatase σ in proteoglycan-mediated neural regeneration regulation

Chien, P. N. & Ryu, S. E., 2013 Feb, In : Molecular Neurobiology. 47, 1, p. 220-227 8 p.

Research output: Contribution to journalReview article

17 Scopus citations

Role of a highly conserved and catalytically important glutamate-49 in the Enterococcus faecalis acetolactate synthase

Lee, M. Y., Lee, S. C., Cho, J. H., Ryu, S. E., Koo, B. S. & Yoon, M. Y., 2013 Jan 1, In : Bulletin of the Korean Chemical Society. 34, 2, p. 669-672 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates

Yu, K. R., Kim, Y. J., Jung, S. K., Ku, B., Park, H., Cho, S. Y., Jung, H., Chung, S. J., Bae, K. H., Lee, S. C., Kim, B. Y., Erikson, R. L., Ryu, S. E. & Kim, S. J., 2013 Aug 1, In : Acta Crystallographica Section D: Biological Crystallography. 69, 8, p. 1522-1529 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structure of the catalytic domain of protein tyrosine phosphatase sigma in the sulfenic acid form

Jeon, T. J., Chien, P. N., Chun, H. J. & Ryu, S. E., 2013 Jul 1, In : Molecules and Cells. 36, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Virtual screening and biochemical evaluation of the inhibitors of dual-specificity phosphatase 26

Park, H., Kyung, A., Lee, H. J., Kang, S., Yoon, T. S., Ryu, S. E. & Jeong, D. G., 2013 Aug 1, In : Medicinal Chemistry Research. 22, 8, p. 3905-3910 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012

Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening

Park, H., Chien, P. N. & Ryu, S. E., 2012 Oct 15, In : Bioorganic and Medicinal Chemistry Letters. 22, 20, p. 6333-6337 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity

Han, Y. M., Lee, S. K., Jeong, D. G., Ryu, S. E., Han, D. C., Kim, D. K. & Kwon, B. M., 2012 Jan 1, In : Bioorganic and Medicinal Chemistry Letters. 22, 1, p. 323-326 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Homophilic interaction of the L1 family of cell adhesion molecules

Wei, C. H. & Ryu, S. E., 2012 Jan 1, In : Experimental and Molecular Medicine. 44, 7, p. 413-423 11 p.

Research output: Contribution to journalReview article

24 Scopus citations

Structural mechanism of disulphide bond-mediated redox switches

Ryu, S. E., 2012 Jun 1, In : Journal of Biochemistry. 151, 6, p. 579-588 10 p.

Research output: Contribution to journalReview article

18 Scopus citations

Structure and catalytic mechanism of human protein tyrosine phosphatome

Kim, S. J. & Ryu, S. E., 2012, In : BMB reports. 45, 12, p. 693-699 7 p.

Research output: Contribution to journalReview article

14 Scopus citations

Structure and design of broadly-neutralizing antibodies against HIV

Ryu, S. E. & Hendrickson, W. A., 2012 Sep 1, In : Molecules and Cells. 34, 3, p. 231-237 7 p.

Research output: Contribution to journalReview article

2 Scopus citations

Structure-based de novo design of Eya2 phosphatase inhibitors

Park, H., Ryu, S. E. & Kim, S. J., 2012 Sep 1, In : Journal of Molecular Graphics and Modelling. 38, p. 382-388 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structure-based virtual screening approach to the discovery of novel PTPMT1 phosphatase inhibitors

Park, H., Kim, S. Y., Kyung, A., Yoon, T. S., Ryu, S. E. & Jeong, D. G., 2012 Jan 15, In : Bioorganic and Medicinal Chemistry Letters. 22, 2, p. 1271-1275 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Virtual screening and biochemical evaluation of mitogen-activated protein kinase phosphatase 4 inhibitors

Park, H., Jeon, J. Y. & Ryu, S. E., 2012 Nov 20, In : Bulletin of the Korean Chemical Society. 33, 11, p. 3772-3776 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1

Wei, C. H., Ryu, S. Y., Jeon, Y. H., Yoon, M-Y., Jeong, D. G., Kim, S. J. & Ryu, S. E., 2011 Nov 1, In : Proteins: Structure, Function and Bioinformatics. 79, 11, p. 3242-3246 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Crystal structure of constitutively monomeric E. coli Hsp33 mutant with chaperone activity

Chi, S. W., Jeong, D. G., Woo, J. R., Lee, H. S., Park, B. C., Kim, B. Y., Erikson, R. L., Ryu, S. E. & Kim, S. J., 2011 Feb 18, In : FEBS Letters. 585, 4, p. 664-670 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Discovery of novel inhibitors of dual-specificity phosphatase pyst2 with structure-based virtual screening

Park, H., Jeon, J. Y., Ryu, S. E. & Kim, S. J., 2011 Jul 20, In : Bulletin of the Korean Chemical Society. 32, 7, p. 2167-2168 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Enhanced chondrogenic marker expression of human mesenchymal stem cells by interaction with both TGF-β3 and hyaluronic acid

Bhang, S. H., Jeon, J. Y., La, W. G., Seong, J. Y., Hwang, J. W., Ryu, S. E. & Kim, B. S., 2011 Jul 1, In : Biotechnology and Applied Biochemistry. 58, 4, p. 271-276 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Exploring binding sites other than the catalytic core in the crystal structure of the catalytic domain of MKP-4

Jeong, D. G., Yoon, T. S., Jung, S. K., Park, B. C., Park, H., Ryu, S. E. & Kim, S. J., 2011 Jan 1, In : Acta Crystallographica Section D: Biological Crystallography. 67, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Identification of novel inhibitors of mitogen-activated protein kinase phosphatase-1 with structure-based virtual screening

Park, H., Jeon, J. Y., Kim, S. Y., Jeong, D. G. & Ryu, S. E., 2011 May 1, In : Journal of Computer-Aided Molecular Design. 25, 5, p. 469-475 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Inhibition of invasion and capillary-like tube formation by retrohydroxamate-based MMP inhibitors

Choi, S. S., Ji, A. R., Yu, S. W., Cho, B. H., Park, J. D., Park, J. H., Lee, H. S., Ryu, S. E., Kim, D. H., Kang, J. H. & Lee, S. T., 2011 Jun 20, In : Bulletin of the Korean Chemical Society. 32, 6, p. 2032-2038 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structural mechanism of the antigen recognition by the L1 cell adhesion molecule antibody A10-A3

Wei, C. H., Lee, E. S., Jeon, J. Y., Heo, Y. S., Kim, S. J., Jeon, Y. H., Kim, K. H., Hong, H. J. & Ryu, S. E., 2011 Jan 3, In : FEBS Letters. 585, 1, p. 153-158 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2010

Crystal structure of ED-Eya2: Insight into dual roles as a protein tyrosine phosphatase and a transcription factor

Jung, S. K., Jeong, D. G., Chung, S. J., Kim, J. H., Park, B. C., Tonks, N. K., Ryu, S. E. & Kim, S. J., 2010 Feb, In : FASEB Journal. 24, 2, p. 560-569 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Identification of two novel VHR phosphatase inhibitors with structure-based virtual screening

Park, H., Jeon, J. Y., Jeong, D. G. & Ryu, S. E., 2010 Dec 20, In : Bulletin of the Korean Chemical Society. 31, 12, p. 3785-3787 3 p.

Research output: Contribution to journalArticle

Identification of tyrosine-nitrated proteins in HT22 hippocampal cells during glutamate-induced oxidative stress

Yoon, S. W., Kang, S., Ryu, S. E. & Poo, H., 2010 Dec, In : Cell Proliferation. 43, 6, p. 584-593 10 p.

Research output: Contribution to journalArticle

14 Scopus citations